Recent Advances in the Development of Sigma Receptor (Radio)Ligands and Their Application in Tumors DOI Creative Commons
Tao Wang, Na Sun, Yuefeng Ma

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(4), P. 951 - 977

Published: March 7, 2025

Cancer ranks among the top triumvirate leading causes of human deaths worldwide. The pathological mechanisms are notably intricate, demonstrating proliferative and metastatic capabilities, which complicate therapeutic interventions. sigma-1 receptor (σ1R) plays a crucial role in tumor survival migration, while sigma-2 (σ2R) is intimately associated with proliferation. This review encapsulated investigation concerning σ1R σ2R neoplasms rigorously summarized ligands radio-ligands development their applications, such as antitumor cell proliferation PET/SPECT imaging tumors. A comprehensive classification discussion was undertaken regarding chemical structures emphasized possibility dual/multitargeted ligands. Ultimately, we discussed effects chiral pharmacological characteristics on affinity pharmacokinetic features vivo, particularly radiopharmaceuticals. functions beneficial resource, fostering ligand deployment stimulating generation innovative ideas for developing

Language: Английский

Recent Advances in the Development of Sigma Receptor (Radio)Ligands and Their Application in Tumors DOI Creative Commons
Tao Wang, Na Sun, Yuefeng Ma

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: 8(4), P. 951 - 977

Published: March 7, 2025

Cancer ranks among the top triumvirate leading causes of human deaths worldwide. The pathological mechanisms are notably intricate, demonstrating proliferative and metastatic capabilities, which complicate therapeutic interventions. sigma-1 receptor (σ1R) plays a crucial role in tumor survival migration, while sigma-2 (σ2R) is intimately associated with proliferation. This review encapsulated investigation concerning σ1R σ2R neoplasms rigorously summarized ligands radio-ligands development their applications, such as antitumor cell proliferation PET/SPECT imaging tumors. A comprehensive classification discussion was undertaken regarding chemical structures emphasized possibility dual/multitargeted ligands. Ultimately, we discussed effects chiral pharmacological characteristics on affinity pharmacokinetic features vivo, particularly radiopharmaceuticals. functions beneficial resource, fostering ligand deployment stimulating generation innovative ideas for developing

Language: Английский

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