Gold(I) N-Heterocyclic Carbene Complexes as Ferroptosis Inducing Anticancer Agents DOI

E. Schlegel,

Zisis Papadopoulos,

Nicolás Montesdeoca

et al.

ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 16(5), P. 856 - 864

Published: April 24, 2025

This study presents the chemical synthesis and biological evaluation of a series gold(I)-N-heterocyclic carbene complexes as potential anticancer agents. The compounds demonstrated broad activity against various cancer cell lines, exhibiting cytotoxicity in low micromolar range. Mechanistic investigations revealed that these preferentially accumulate mitochondria cells, where they induce generation reactive oxygen species lipid peroxides, ultimately triggering ferroptosis. Further studies multicellular tumor spheroids confirmed compounds' ability to penetrate three-dimensional cellular structures effectively eradicate them at concentrations. work represents first known example complex inducing ferroptosis, expanding therapeutic gold(I)-based metallodrugs.

Language: Английский

Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development DOI
Ashish Yadav, Samya Banerjee,

Arif Ali Mandal

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7161 - 7181

Published: Feb. 20, 2025

Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.

Language: Английский

Citations

0
An efficient ICD inducer based on Ir(III) cyclometalated complex for anticancer and anti-migration effects towards cisplatin-resistant cancer cells DOI
Jingyue Zhao,

Xiangyu Dai,

Mengdi Lv

et al.

Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122601 - 122601

Published: Feb. 1, 2025

Language: Английский

Citations

0
Overcoming Radiation-induced PD-L1 and Cox-2 Upregulation by Nitric Oxide Gas Nanogenerator to Sensitize Radiotherapy of Lung Cancer DOI
Jiajun Chen, Xin Jiang, Lijie Zhu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123335 - 123335

Published: April 1, 2025

Language: Английский

Citations

0
Gold(I) N-Heterocyclic Carbene Complexes as Ferroptosis Inducing Anticancer Agents DOI

E. Schlegel,

Zisis Papadopoulos,

Nicolás Montesdeoca

et al.

ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 16(5), P. 856 - 864

Published: April 24, 2025

This study presents the chemical synthesis and biological evaluation of a series gold(I)-N-heterocyclic carbene complexes as potential anticancer agents. The compounds demonstrated broad activity against various cancer cell lines, exhibiting cytotoxicity in low micromolar range. Mechanistic investigations revealed that these preferentially accumulate mitochondria cells, where they induce generation reactive oxygen species lipid peroxides, ultimately triggering ferroptosis. Further studies multicellular tumor spheroids confirmed compounds' ability to penetrate three-dimensional cellular structures effectively eradicate them at concentrations. work represents first known example complex inducing ferroptosis, expanding therapeutic gold(I)-based metallodrugs.

Language: Английский

Citations

0