Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(12), P. 1614 - 1614
Published: Nov. 29, 2024
Background/Objectives:
Drugs
exhibiting
poor
aqueous
solubility
present
a
challenge
to
efficient
delivery
the
site
of
action.
Spanlastics
(a
nano,
surfactant-based
drug
system)
have
emerged
as
powerful
tool
improve
solubility,
bioavailability,
and
This
study
aimed
better
understand
factors
affecting
physicochemical
properties
spanlastics,
quantify
their
effects,
use
them
enhance
bioavailability
famotidine
(FMT),
model
histamine
H2
receptor
antagonist
(BCS
class
IV).
Methods:
FMT
was
incorporated
into
nano-spanlastics
system.
The
ethanol
injection
method,
Box–Behnken
design,
mathematical
modeling
were
utilized
fabricate
famotidine-loaded
optimize
formula.
characterized
for
particle
size,
polydispersity
index,
zeta
potential,
entrapment
efficiency,
loading,
compatibility
excipients
(using
DSC),
in
vitro
release,
vivo
pharmacokinetics.
Results:
Span
60
(the
non-ionic
surfactant)
tween
edge
activator)
gave
rise
spanlastics
with
best
characteristics.
optimal
spanlastic
formulation
exhibited
small
size
(<200
nm),
appropriate
index
(<0.4),
potential
(>−30
mV).
efficiency
loading
optimum
formula
assured
its
suitability
hydrophobic
well
practicability
use.
DSC
all
components.
release
manifested
biphasic
pattern,
resulting
fast
onset
sustained
effect.
also
showed
enhanced
Cmax,
AUC0–24,
bioavailability.
Conclusions:
improved
dissolution,
characteristics,
membrane
permeation,
pharmacokinetic
behavior.
The Journal of Physical Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Eutectic
solvents
(ESs)
have
shown
great
efficiency
on
increasing
the
solubility,
stability,
and
bioactivity
of
active
pharmaceutical
ingredients
(APIs)
in
recent
research
studies.
Curcumin
is
an
important
API
driven
from
natural
plants,
which
displayed
a
series
biofunctions
like
antibacterials,
anti-inflammatory,
anticancer
activities
etc.
However,
its
poor
water
solubility
stability
hindered
further
clinic
application.
Herein,
novel
ESs
based
matrine
fatty
acids
(i.e.,
octanoic
acid,
decanoic
lauric
acid)
were
developed.
The
phase
behavior
cytotoxicity
these
investigated.
Moreover,
prepared
excellent
ability
enhancing
curcumin
with
highest
being
28
mg/mL
at
298
K,
was
nearly
50000-fold
than
that
water.
showed
high
ESs,
where
only
10%
decomposed
under
light
irradiation
for
6
h.
Furthermore,
biofilms
ES
solutions
been
antioxidant
antibacterial
activities.
To
summarize,
eutectic
systems
provide
new
strategy
application
curcumin.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 574 - 574
Published: Jan. 27, 2025
This
study
investigates
the
structural
and
transport
properties
of
SDS,
CTAB,
SB3-12
micelles
in
three
deep
eutectic
solvents
(DESs),
Ethaline,
Glyceline,
Reline,
using
molecular
dynamics
(MD)
simulations.
The
influence
solvent
composition
on
micelle
morphology,
interactions,
was
explored,
revealing
key
differences
driven
by
DES
environment.
Structural
analyses,
including
eccentricity
radius
gyration,
demonstrated
that
shape
compactness
vary
significantly
depending
solvent.
In
Ethaline
larger
showed
significant
deviations
from
spherical
shapes,
while
Glyceline
became
more
compact,
particularly
those
formed
SB3-12.
Radial
distribution
functions
highlighted
different
levels
micelle–solvent
with
SDS
showing
strong
interactions
HBD
components
exhibiting
prominent
self-interaction.
According
to
hydrogen
bonding
analysis,
slightly
disrupt
bond
network,
establishing
most
connections.
property
analysis
revealed
have
lower
diffusion
coefficients,
whereas
smaller
enhance
DESs’
component
mobility.
These
findings
advance
understanding
behavior
DESs
also
help
optimization
DES–surfactant
systems
for
applications
such
as
electrodeposition,
nanomaterial
templating,
drug
delivery.
Future
research
will
focus
surfactant
surfaces
further
improve
these
applications.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(12), P. 8977 - 8985
Published: Jan. 1, 2025
The
scattering
techniques,
including
small-angle
X-ray
and
neutron
scattering,
revealed
how
DES
concentration
skin
hydration
affect
stratum
corneum
lipid
structure
drug
carrier
penetration.
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 23
Published: April 22, 2025
This
review
explores
green
approaches
to
enhance
poorly
water-soluble
drug
solubility.
Implementing
sustainable
and
techniques,
it
provides
a
comprehensive
overview
of
advancements
applications
in
development.
Drug
solubility
is
key
challenge
pharmaceutical
research,
affecting
bioavailability
efficacy.
Conventional
methods
often
rely
on
hazardous
solvents
energy-intensive
processes,
posing
environmental
safety
concerns.
emphasizes
chemistry
principles
as
alternatives
while
supporting
global
sustainability
goals.
Natural
biodegradable
polymers
solid
dispersions
offer
effective,
eco-friendly
enhancement.
The
application
supercritical
CO2
demonstrates
significant
potential
solvent
for
enhancement,
offering
scalability
minimizing
impact.
Plant-derived
renewable
excipients
alternative
synthetic
additives.
face
formulation,
solubility,
batch
variability
issues.
Deep
eutectic
ionic
liquids
stability,
regulatory
hurdles,
toxicity
risks,
hygroscopicity.
Supercritical
fluid
technology
requires
costly
equipment
precise
optimization.
Green
co-crystallization
faces
co-former
selection,
scalability,
stability
Further
refinement,
validation,
industrial
feasibility
studies
are
needed.
enhancement
regulatory,
cost
challenges.
Some
limited
gains
Ensuring
cost-effectiveness,
viability,
compliance
broader
adoption.
offers
solution
Integrating
these
improves
efficiency,
safety,
highlights
the
need
further
research
adoption
delivery
approaches.
