Dyad System of BOAHY-BODIPY Conjugates as Novel Photoswitchable Photosensitizers for Photodynamic Therapy

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Photodynamic therapy (PDT) offers minimally invasive and repeatable cancer treatment options. Despite advancements in photosensitizer (PS) design, the optical control of PS activation remains unexplored. Here, we present first photoswitchable based on a BOAHY-BODIPY dyad system. Inspired by BODIPY multimer structures BOAHY's photoisomerization properties, designed mono-(4 series) bis-BOAHY-BODIPY (5 conjugates. These dyads primarily generate reactive oxygen species via type-I process under white light. Notably, 4 series compounds demonstrated effective photocytotoxicity photoswitching properties vitro. Building these, iodinated monoconjugates to develop highly efficient PS, 6b, which exhibited enhanced intersystem crossing type-II generation due reduced singlet-triplet energy gap. As demonstration PDT agents, this strategy introduces new approach with significant potential for selective clinical applications.

Language: Английский

Unexpected acridine-fused aza-BODIPY photosensitizer originated from pyrrole with a –CH2–CH2− chain

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 46, P. 102766 - 102766

Published: May 18, 2025

Language: Английский

Reply to “Comment on ‘Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights’”

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 22(1), P. 585 - 587

Published: Dec. 5, 2024

Language: Английский