Metalla-Aromatic Oligomers: Efficient Photocatalytic Activation for Phototherapy DOI
Shiyan Chen, Guotao Yuan, Liu Wang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Monodisperse oligomers, positioned as intermediates between polymers and small molecules, retain certain reactivities of molecules while simultaneously displaying the initial aggregation characteristics polymers. This distinctive structure bestows on them with significant potential for a wide range applications. In this study, series carbolong osmium oligomers (Os1-Os4) corresponding polymer were evaluated photocatalysts. It was discovered that their molar absorption coefficients reactive oxygen species generation rose π-conjugation length, peaking at polymerization degree 4. Moreover, Os4 facilitates photocatalytic oxidation nicotinamide adenine dinucleotide (NADH) to its oxided form, NAD+. vitro experiments demonstrated had strongest phototoxicity index in cells hypoxic conditions, highlighting efficacy tumor. Metabolomic analyses indicated exerted photocytotoxicity by disrupting purine metabolism. These insights will guide future design π-conjugated metal advancing

Language: Английский

Sustainable Lactic Acid Production: Optimization Yield from Sugarcane and Beet Molasses through Fermentation DOI Creative Commons

Nahla M. Salatein,

Rawan K. Hassan,

Rana Adel Ibrahim

et al.

Results in Engineering, Journal Year: 2025, Volume and Issue: 26, P. 105161 - 105161

Published: May 1, 2025

Language: Английский

Citations

0
Metalla-Aromatic Oligomers: Efficient Photocatalytic Activation for Phototherapy DOI
Shiyan Chen, Guotao Yuan, Liu Wang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

Monodisperse oligomers, positioned as intermediates between polymers and small molecules, retain certain reactivities of molecules while simultaneously displaying the initial aggregation characteristics polymers. This distinctive structure bestows on them with significant potential for a wide range applications. In this study, series carbolong osmium oligomers (Os1-Os4) corresponding polymer were evaluated photocatalysts. It was discovered that their molar absorption coefficients reactive oxygen species generation rose π-conjugation length, peaking at polymerization degree 4. Moreover, Os4 facilitates photocatalytic oxidation nicotinamide adenine dinucleotide (NADH) to its oxided form, NAD+. vitro experiments demonstrated had strongest phototoxicity index in cells hypoxic conditions, highlighting efficacy tumor. Metabolomic analyses indicated exerted photocytotoxicity by disrupting purine metabolism. These insights will guide future design π-conjugated metal advancing

Language: Английский

Citations

0