Metal-organic
frameworks
(MOFs)
are
porous,
crystalline
solids
constructed
from
organic
linkers
and
inorganic
nodes
that
have
been
widely
studied
for
applications
in
gas
storage,
chemical
separations,
drug
delivery.
Owing
to
their
highly
modular
structures
tunable
pore
environments,
we
propose
MOFs
significant
untapped
potential
as
catalysts
reagents
relevant
the
synthesis
of
next-generation
therapeutics.
Herein,
outline
properties
make
them
promising
synthetic
chemistry,
including
new
reactivity
selectivity,
enhanced
robustness,
user-friendly
preparation.
In
addition,
challenges
facing
field
directions
maximize
utility
synthesis.
This
perspective
aims
bring
together
MOF
communities
develop
heterogeneous
platforms
capable
achieving
transformations
can-not
be
replicated
by
homogeneous
systems.
Journal of Medicinal Chemistry,
Journal Year:
2019,
Volume and Issue:
62(21), P. 9375 - 9414
Published: May 3, 2019
Introducing
novel
strategies,
concepts,
and
technologies
that
speed
up
drug
discovery
the
development
cycle
is
of
great
importance
both
in
highly
competitive
pharmaceutical
industry
as
well
academia.
This
Perspective
aims
to
present
a
"big-picture"
overview
recent
strategic
innovations
medicinal
chemistry
discovery.
Journal of Medicinal Chemistry,
Journal Year:
2018,
Volume and Issue:
61(15), P. 6421 - 6467
Published: April 5, 2018
The
practices
and
tactics
employed
in
successful
optimizations
are
examined,
judged
from
the
trajectories
of
ligand
efficiency
property
evolution.
A
wide
range
targets
is
analyzed,
encompassing
a
variety
hit
finding
methods
(HTS,
fragments,
encoded
library
technology)
types
molecules,
including
those
beyond
rule
five.
wider
employment
metrics
lipophilicity
control
evident
contemporary
practice
impact
on
quality
demonstrable.
What
clear
that
while
different,
molecules
almost
invariably
among
most
efficient
for
their
target,
even
at
extremes.
Trajectory
mapping,
based
principles
rather
than
rules,
useful
assessing
progress
benchmarking
against
competitors
property-dependent
risks.
Chemistry of Materials,
Journal Year:
2023,
Volume and Issue:
35(13), P. 4883 - 4896
Published: June 21, 2023
Metal–organic
frameworks
(MOFs)
are
porous
crystalline
solids
constructed
from
organic
linkers
and
inorganic
nodes
that
have
been
widely
studied
for
applications
in
gas
storage,
chemical
separations,
drug
delivery.
Owing
to
their
highly
modular
structures
tunable
pore
environments,
we
propose
MOFs
significant
untapped
potential
as
catalysts
reagents
relevant
the
synthesis
of
next-generation
therapeutics.
Herein,
outline
properties
make
them
promising
synthetic
chemistry,
including
new
reactivity
selectivity,
enhanced
robustness,
user-friendly
preparation.
In
addition,
challenges
facing
field
directions
maximize
utility
synthesis.
This
Perspective
aims
bring
together
MOF
communities
develop
heterogeneous
platforms
capable
achieving
transformations
cannot
be
replicated
by
homogeneous
systems.
Analytica Chimica Acta,
Journal Year:
2024,
Volume and Issue:
1304, P. 342559 - 342559
Published: March 30, 2024
α-Synuclein
(αS)
aggregation
is
the
main
neurological
hallmark
of
a
group
neurodegenerative
disorders,
collectively
referred
to
as
synucleinopathies,
which
Parkinson's
disease
(PD)
most
prevalent.
αS
oligomers
are
elevated
in
cerebrospinal
fluid
(CSF)
PD
patients,
standing
biomarker
for
diagnosis.
However,
methods
early
detection
still
lacking.
We
have
recently
identified
amphipathic
22-residue
peptide
PSMα3
high-affinity
binder
toxic
oligomers.
displayed
excellent
selectivity
and
reproducibility,
binding
with
affinities
low
nanomolar
range
without
detectable
cross-reactivity
functional
monomeric
αS.
In
this
work,
we
leveraged
these
unique
properties
design
plasmonic-based
biosensor
direct
under
label-free
conditions.
describe
integration
lab-on-a-chip
plasmonic
platform
suitable
point-of-care
measurements
CSF
samples
real-time
at
an
affordable
cost,
providing
innovative
diagnosis
clinic.
ACS Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
10(6), P. 1856 - 1870
Published: May 9, 2024
Antiparasitic
drug
development
stands
as
a
critical
endeavor
in
combating
infectious
diseases
which,
by
affecting
the
well-being
of
humans,
animals,
and
environment,
pose
significant
global
health
challenges.
In
scenario
where
conventional
pharmacological
interventions
have
proven
inadequate,
One
Health
approach,
which
emphasizes
interdisciplinary
collaboration
holistic
solutions,
emerges
vital
strategy.
By
advocating
for
integration
principles
into
R&D
pharmaceutical
pipeline,
this
Perspective
promotes
green
chemistry
methodologies
to
foster
environmentally
friendly
antiparasitic
drugs
both
human
animal
health.
Moreover,
it
highlights
urgent
need
address
vector-borne
parasitic
(VBPDs)
within
context
Health-driven
sustainable
development,
underscoring
pivotal
role
medicinal
chemists
driving
transformative
change.
Aligned
with
Sustainable
Development
Goals
(SDGs)
European
Green
Deal,
explores
application
12
Principles
Chemistry
systematic
framework
guide
discovery
production
efforts
VBPD.
Through
constant
commitment
sustainability,
field
can
overcome
challenges
posed
VBPD
while
promoting
environmental
responsibility.
Serving
call
action,
scientists
are
urged
integrate
concepts
routine
practices,
thereby
paving
way
more
pipeline
drugs.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2021,
Volume and Issue:
9(37), P. 12461 - 12475
Published: Aug. 31, 2021
To
avoid
adverse
side
effects
of
chemicals,
pharmaceuticals,
and
their
transformation
products
(TPs)
in
the
environment,
substances
should
be
designed
to
fully
mineralize
environment
at
end-of-life
while
ensuring
a
degree
stability
as
needed
for
application.
These
considerations
implemented
very
beginning
chemical's
pharmaceutical's
design
(Benign
by
Design,
BbD)
meet
requirements
set
planetary
boundaries
upcoming
legal
frameworks
(e.g.,
"Chemicals
Strategy
Sustainability
towards
Toxic-Free
Environment"
European
Commission
(EC)).
In
silico
tools
are
already
being
drug
discovery
process
assessment
chemicals
pharmaceuticals.
The
advantage
which
is
avoiding
or
least
minimizing
animal
testing
chemical
waste
due
experimental
well
reducing
time
market.
However,
literature,
there
just
few
examples
how
could
BbD
process.
Therefore,
this
study
suggests
workflow
supporting
practitioners
designing
new
environmentally
mineralizing
This
would
also
result
much
faster
less
expensive
than
starting
with
repetitive
synthesis
subsequent
improve
compounds'
properties.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
In
2015,
the
United
Nations
officially
launched
Sustainable
Development
Goals
(SDGs)
as
"the
blueprint
to
achieve
a
better
and
more
sustainable
future
for
all.
They
address
global
challenges
we
face,
including
those
related
poverty,
inequality,
climate
change,
environmental
degradation,
peace
justice.
The
17
are
all
interconnected,
in
order
leave
no
one
behind,
it
is
important
that
them
by
2030".
Here,
have
embedded
medicinal
chemistry
key
player
SDGs.
We
firmly
believe
can
must
contribute
world
with
an
improved
quality
of
life
taken
critical
look
at
each
SDGs,
dividing
into
Priority
Foundational,
analyzed
how
has
impact
on
them.
Although
much
been
done,
determined
make
progress
this
area.
