MOFganic Chemistry: Challenges and Opportunities for Metal-Organic Frameworks in Synthetic Organic Chemistry DOI Creative Commons

Bayu Ahmad,

Kaitlyn T. Keasler, Emily Stacy

et al.

Published: March 30, 2023

Metal-organic frameworks (MOFs) are porous, crystalline solids constructed from organic linkers and inorganic nodes that have been widely studied for applications in gas storage, chemical separations, drug delivery. Owing to their highly modular structures tunable pore environments, we propose MOFs significant untapped potential as catalysts reagents relevant the synthesis of next-generation therapeutics. Herein, outline properties make them promising synthetic chemistry, including new reactivity selectivity, enhanced robustness, user-friendly preparation. In addition, challenges facing field directions maximize utility synthesis. This perspective aims bring together MOF communities develop heterogeneous platforms capable achieving transformations can-not be replicated by homogeneous systems.

Language: Английский

Acid‐Controlled Regional Diverse Synthesis of CF3‐Containing Ketoimines and Application in the Construction of Bispiro[oxindole‐pyrrolidine‐benzothiophenone]s DOI
Shuo Sun, Danna Chen,

Hai Guo

et al.

European Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 26(31)

Published: July 11, 2023

Abstract Here described an acid‐controlled regional diverse synthesized process of CF 3 ‐containing ketoimines by the condensation benzo[ b ]thiophene‐2,3‐dione and 2,2,2‐trifluoroethlamine. The imines obtained at either 2‐position or 3‐position can be further used as substrates in asymmetric organocatalyzed [3+2]‐cycloaddition reactions, leading to a library regiodiverse bispiro‐compounds with 85–96 % yield 65–99 ee .

Language: Английский

Citations

1
MOFganic Chemistry: Challenges and Opportunities for Metal-Organic Frameworks in Synthetic Organic Chemistry DOI Creative Commons

Bayu Ahmad,

Kaitlyn T. Keasler, Emily Stacy

et al.

Published: March 30, 2023

Metal-organic frameworks (MOFs) are porous, crystalline solids constructed from organic linkers and inorganic nodes that have been widely studied for applications in gas storage, chemical separations, drug delivery. Owing to their highly modular structures tunable pore environments, we propose MOFs significant untapped potential as catalysts reagents relevant the synthesis of next-generation therapeutics. Herein, outline properties make them promising synthetic chemistry, including new reactivity selectivity, enhanced robustness, user-friendly preparation. In addition, challenges facing field directions maximize utility synthesis. This perspective aims bring together MOF communities develop heterogeneous platforms capable achieving transformations can-not be replicated by homogeneous systems.

Language: Английский

Citations

0