Synthesis and investigation of new indole‐containing vinyl sulfide derivatives: In silico and in vitro studies for potential therapeutic applications

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 21(2)

Published: Dec. 20, 2023

Indoles featuring organosulfur compounds serve as privileged structural scaffolds in various biologically active compounds. This study investigates the biological properties of five synthetic sulphenyl vinyl indoles (3 a-e) using both silico and vitro methods. Computational analyses employing Swiss ADME Molinspiration software reveal remarkable inhibitory activity compound 3 d against proteases kinases (scores 0.18 0.06, respectively). Furthermore, it demonstrates ability to modulate ionic G protein-coupled receptors (scores: -0.06 0.31, respectively) serves a ligand for nuclear (score 0.15). In investigations highlight compounds' efficacy countering ABTS

Language: Английский

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Short Lecture "Optimisation and biochemometric analysis of Morus alba root bark extracts against acute respiratory infections"

Planta Medica, Journal Year: 2023, Volume and Issue: 89(14), P. 1298 - 1299

Published: Nov. 1, 2023

Language: Английский

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Cheminformatic and biochemometric strategies for the discovery of natural products against SARS-CoV-2

Planta Medica, Journal Year: 2023, Volume and Issue: 89(14), P. 1421 - 1421

Published: Nov. 1, 2023

Language: Английский

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Short Lecture “Spotlight on Morus alba root bark compounds and extracts in search of inhalable natural product formulations against acute respiratory infections”

Planta Medica, Journal Year: 2023, Volume and Issue: 89(14), P. 1278 - 1278

Published: Nov. 1, 2023

Language: Английский

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