Organic reactions,
Journal Year:
2022,
Volume and Issue:
unknown, P. 1 - 654
Published: June 13, 2022
This
chapter
describes
the
use
of
allyl‐
and
vinylstannane
reagents
for
a
variety
radical‐based
transformations.
The
processes
discussed
include
direct
addition
radicals
to
vinylstannanes,
multicomponent
or
multistep
cascade
reactions
that
terminate
with
an
intermolecular
allylation
vinylation,
cyclizations
onto
moieties,
allylstannylation
reactions.
Allylation
have
provided
framework
exploration
stereoselective
radical
reactions,
models
explaining
stereoselectivity
obtained
by
number
approaches
are
presented.
Examples
illustrate
scope
applications
in
synthesis,
as
well
ways
newly
introduced
allyl
vinyl
groups
been
subsequently
manipulated.
A
comparison
is
made
vinylation
employ
non‐tin‐based
reagents.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(10), P. 1918 - 1923
Published: March 7, 2022
An
inimitable
illustration
of
the
green-light-induced
synthesis
thio-functionalized
pyrroles
has
been
established
using
β-ketodinitriles
and
thiophenols
as
reacting
partners
eosin
Y
photocatalyst.
Large-scale
some
useful
synthetic
modifications
are
also
demonstrated.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(11)
Published: Jan. 29, 2024
Abstract
2H
‐arizines
are
important
three‐membered
heterocycles
in
organic
chemistry.
Recently,
many
advances
the
synthesis
and
functionalization
of
have
been
reported.
Neber
rearrangement,
isomerization
isoxazole,
oxidation
enamine,
C−H
bond
activation,
decomposition
vinyl
azide,
alkyne,
multi‐step
developed
for
efficient
assembly
‐azirines.
As
versatile
highly
strained
unsaturated
heterocycles,
‐azirines
can
be
used
as
distinctive
building
blocks
towards
significant
functional
groups,
attracted
extensive
attention
fabrication
numerous
heterocycles.
Recent
studies
focused
on
[3+n]
ring‐expansion
reactions,
nucleophilic
addition
C=N
double
or
continuous
followed
by
cyclization,
ring‐opening
to
acyclic
compounds,
substitution
sp
3
‐C−H
One
most
critical
challenges
is
seeking
a
selective
opening
specific
three
bonds
azirine
circle,
some
what
achieved
basis
metal
catalyst,
photocatalysis,
combination
catalyst
photocatalysis.
In
this
review,
recent
involving
reactivity
accompanied
with
breakthroughs
summarized.
The
review
mainly
covers
period
from
2019
2023.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(21), P. 3978 - 3983
Published: May 18, 2023
The
unprecedented
dimerizations
of
2H-azirines
have
been
developed
under
the
catalysis
palladium
and
silver.
Upon
changing
reaction
conditions,
fully
aryl-substituted
pyrrole
pyrimidine
derivatives
were
furnished
in
moderate
yields
with
regiospecificity,
respectively.
Control
experiments
uncovered
distinct
catalytic
effects
two
transition
metals,
proposed
cycles
plausibly
rationalized
chemodivergence
regioselectivity.
Journal of Saudi Chemical Society,
Journal Year:
2024,
Volume and Issue:
28(2), P. 101831 - 101831
Published: March 1, 2024
2H-azirines
have
represented
versatile
building
motifs
in
the
domain
of
organic
chemistry
owing
to
their
excellent
reaction
activity
induced
by
high
strain
three-membered
ring
species.
Over
past
decades,
brilliant
achievements
been
made
2H-azirine
involving
construction
as
well
transformation
such
functional
compounds.
In
presence
transition
metals,
strong
bases
or
oxidants,
could
be
converted
into
corresponding
products
under
harsh
conditions.
Different
from
traditional
catalytic
methods,
utilization
photochemistry
has
proved
an
extremely
fascinating
protocol
that
facilitates
blocks
diverse
substrates
and
further
conversion
various
derivatives
with
interesting
biological
activities.
this
regard,
more
light-driven
synthetic
approaches
featuring
efficiency
mild
conditions
developed.
Herein,
we
summarized
accessibility
applications
powerful
precursors
key
intermediates
for
synthesis
biologically
promising
molecules
photocatalytic
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(38)
Published: May 8, 2024
An
efficient
chromoselective
photochemical
process
is
presented
for
the
synthesis
of
2H-azirines
and
1,3-diazabicylo[3.1.0]hex-3-enes
from
readily
available
vinyl
azides.
The
method
exploits
continuous
flow
photochemistry
to
enable
safe
consumption
hazardous
azide
group
provides
uniform
irradiation
using
high-power
LEDs
at
365-450
nm.
Additionally,
a
scaled
telescoped
has
been
developed
providing
access
drug-like
1,6-dihydropyrimidines
pyrimidines
via
integrated
ring-expansion
oxidation
reactions.
Given
prevalence
various
azacyclic
targets
in
pharmaceutical,
agrochemical
materials
applications
it
anticipated
that
this
methodology
will
further
exploitations
these
important
scaffolds.
Chinese Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
40(6), P. 719 - 724
Published: Nov. 24, 2021
Comprehensive
Summary
A
visible‐light‐promoteded
[3
+
2]
cycloaddition
reaction
of
2
H
‐azirines
with
quinones
has
been
developed
under
mild
conditions.
The
provides
a
general
and
efficient
strategy
for
the
synthesis
benzo[
f
]isoindole‐4,9‐diones
scaffold
via
tandem
cyclization/oxidative
aromatization
molecular
oxygen.
Furthermore,
preliminary
studies
photocatalytic
properties
show
that
3
can
be
used
as
photocatalysts
in
several
organic
transformations.
