The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(24), P. 16887 - 16894
Published: Dec. 1, 2022
Diarylselenides
are
a
representative
class
of
molecules
in
organoselenium
compounds.
We
herein
report
Rh-catalyzed
direct
diarylation
selenium
with
benzamide
derivatives.
The
use
elemental
as
the
Se
source
is
intriguing
terms
atom
economy,
cost,
stability,
and
handling.
A
series
diarylselenides
amide
moieties
were
readily
accessible
through
directed
C-H
activation.
intermediacy
electrophilic
Se(IV)
species
was
indicated
by
control
experiments.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(21), P. 4416 - 4421
Published: Aug. 7, 2024
Abstract
A
Palladium
catalyzed
C4‐
alkylation
of
indoles
using
epoxide
as
an
alkylating
agent
and
pivaloyl
a
weak
chelating
group
has
been
demonstrated.
variety
substituted
epoxides
furnished
the
desired
β‐indolylethyl
alcohols
in
38%–87%
yields.
Control
experiments
indicate
that
C−H
cleavage
step
is
irreversible.
The
resultant
hydroxyl
converted
to
various
functional
groups
demonstrate
synthetic
utility
this
protocol.
Chinese Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
43(1), P. 156 - 156
Published: Jan. 1, 2023
The
intrinsic
directing
group
is
a
functional
in
the
substrates
and
also
serves
as
an
essential
component
products.Thus,
preinstallation
removal
of
groups
are
avoided.7-Azaindole
has
been
used
for
N-aryl-C-H
functionalization
N-aryls
under
catalysis
transition
metals.Utilizing
C-H
strategy,
numerous
were
installed
into
ortho-position
corresponding
N-aryl-7-azaindoles.In
this
review,
recent
achievements
on
transition-metal
catalyzed
N-aryl
ortho-C-H
directed
by
7-azaindole
summarized.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 28, 2024
Abstract
This
study
highlights
the
significance
of
Ullmann
coupling
reaction
in
modern
organic
synthesis
and
advances
catalytic
methodologies
through
introduction
a
kanamycin−copper
complex
as
highly
efficient
catalyst
for
diverse
N
−aryl
compounds.
We
demonstrate
catalyst's
versatility
by
synthesizing
20
diaryl−amine
instances,
21
Ar
(het)−
compounds,
10
miscellaneous
examples.
NMR,
IR,
UV
spectroscopy
offer
insights
into
behaviour.
Additionally,
DFT
studies
support
proficiency
generating
SO
4
−
⋅
radicals
stabilizing
with
amino
sugar
moieties.
Ex‐situ
NMR
experiments
confirm
ternary
complex‐based
mechanism
at
concentrations
below
0.1
μM.
Furthermore,
we
showcase
degradation
methylene
blue
to
its
precursor
amine
under
optimized
conditions.
Overall,
this
research
underscores
potential
condensation
reactions
contemporary
contributes
significantly
advancement
methodologies.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(24), P. 16887 - 16894
Published: Dec. 1, 2022
Diarylselenides
are
a
representative
class
of
molecules
in
organoselenium
compounds.
We
herein
report
Rh-catalyzed
direct
diarylation
selenium
with
benzamide
derivatives.
The
use
elemental
as
the
Se
source
is
intriguing
terms
atom
economy,
cost,
stability,
and
handling.
A
series
diarylselenides
amide
moieties
were
readily
accessible
through
directed
C-H
activation.
intermediacy
electrophilic
Se(IV)
species
was
indicated
by
control
experiments.
