The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
A
new
access
to
substituted
pyridines
was
developed
from
iodoenones.
This
two-step
procedure
involves
a
Sonogashira
coupling
with
free
alkyne
containing
nosylamide
followed
by
thiophenol
treatment
in
basic
conditions
that
triggers
nosyl
deprotection,
Michael-retro-Michael
process,
condensation,
and
isomerization
cascade
yield
the
heterocycle.
method
enables
introduction
of
different
substituents
at
several
pyridine
positions.
approach
offers
synthetic
opportunities
produce
heterocycles
present
many
bioactive
compounds.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(24), P. 4968 - 4972
Published: Jan. 1, 2024
A
simple,
efficient,
green
method
for
constructing
substituted
phenanthridine
with
nitroaromatic
hydrocarbons
and
aromatic
aldehydes
alkyl
under
visible
light.
Polycyclic aromatic compounds,
Journal Year:
2023,
Volume and Issue:
44(8), P. 5412 - 5423
Published: Oct. 2, 2023
AbstractA
green
and
facile
synthesis
of
1-(α-aminoalkyl)-2-naphthols,
generally
called
Betti
bases
(BB)
in
the
presence
Baker's
yeast
(BY),
acts
as
an
efficient
catalyst,
ethanol
a
solvent.
In
this
methodology,
BY
is
used
first
time
biocatalyst
(enzyme).
This
protocol
has
some
inherent
advantages,
such
mild
reaction
conditions,
no
environmental
pollution,
simple
work
up,
need
column
chromatography,
diversity
reactant
desired
1-(α-aminoalkyl)-2-naphthols
(Betti
bases)
(4a-r)
are
obtained
good-to-excellent
yields.
report
on
yeast-catalyzed
(BYC)
for
BB.
present
bio-catalytical
route
synthesizing
BB
biocatalysts
like
anticipated
to
open
gateway
synthesized
complexed
biological
active
molecules
counting
BB.HIGHLIGHTSA
amino
alkyl
naphthols
by
using
catalyst
solvent.The
Yeast
multi
component
ReactionThe
advantages
methods
reactant,
coloumn
chromatography
yield
(4a-r).The
totally
carried
out
under
envirnmentally
friendly
condition
solvent
EtOH.It
that
s
thesis
will
new
bases.Keywords:
yeastgreen
synthesismulti-component
reactionbetti
reaction1-(α-aminoalkyl)-2-naphthols
AcknowledgementThe
authors
thankful
Dean
School
Sciences,
Maulana
Azad
National
Urdu
University
(MANUU),
Hyderabad
500032,
Telangana,
India,
encouraging
research
activities
providing
basic
facilities
work.Authors'
contributionsThe
author's
contribution
above
study
manuscript
follows.Ms.
Samreen
Kauser
scholar
part
her
work.
She
involved
designing,
experimental
drafting
manuscript.
Dr.
Qasim
Ullah
supervisor
Ms.
finalizing
etc.
Salman
Ahmad
Khan
contributed
toward
drafting,
english
language
edition,
grammatical
corrections
results
discussion
analytical
analysis.
Mohammed
Arifuddin,
conceptualization
optimization
condition,
literature
search
writing
Aram
Rehman,
Research
data
collections.Disclosure
statementAll
declare
there
conflicts
interest.
The
spectral
got
from
SPARK
ANALYTICAL,
payment
basis.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
A
new
access
to
substituted
pyridines
was
developed
from
iodoenones.
This
two-step
procedure
involves
a
Sonogashira
coupling
with
free
alkyne
containing
nosylamide
followed
by
thiophenol
treatment
in
basic
conditions
that
triggers
nosyl
deprotection,
Michael-retro-Michael
process,
condensation,
and
isomerization
cascade
yield
the
heterocycle.
method
enables
introduction
of
different
substituents
at
several
pyridine
positions.
approach
offers
synthetic
opportunities
produce
heterocycles
present
many
bioactive
compounds.
