RSC Advances,
Journal Year:
2022,
Volume and Issue:
12(23), P. 14502 - 14508
Published: Jan. 1, 2022
Herein,
we
describe
a
simple
and
general
multi-component
synthesis
of
5-arylselanyluracils
by
the
regioselective
C-H
selenation
uracils.
Reactions
uracils
with
arylboronic
acid
Se
powder
in
presence
AgNO3
(10
mol%)
at
120
°C
under
aerobic
conditions
afforded
various
5-arylselanyluracils.
The
source
introduced
selanyl
group
was
prepared
from
commercially
available
reaction
system,
thereby
ensuring
efficient
protocol.
This
represents
first
example
5-arylselanyluracil
system.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(4), P. 490 - 495
Published: Jan. 24, 2023
Abstract
An
N‐heterocyclic
carbene
(NHC)
catalyzed
asymmetric
[3+3]
annulation
of
α
‐bromoenals
with
5‐aminopyrazoles
is
described.
Using
the
established
methodology,
a
structurally
diverse
set
high
value
dihydropyrazolo[3,4‐
b
]pyridine‐6‐ones
were
efficiently
constructed
in
yields
(up
to
99%)
excellent
enantioselectivities
>99%).
The
easily
available
starting
materials,
broad
substrate
scope,
mild
reaction
conditions,
yield
and
enantioselectivity
make
this
strategy
attractive
for
construction
pyrazolo‐fused
pyridone
derivatives.
magnified
image
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Aug. 31, 2023
In
this
paper,
we
report
an
eco-friendly
approach
for
the
C(sp2)-H
bond
selenylation
of
imidazopyridines
and
other
N-heteroarenes
as
well
simple
arenes
at
ambient
temperature.
This
new
protocol
consists
reaction
between
(N-hetero)-arenes
diorganyl-diselenides
trichloroisocyanuric
acid
(TCCA)-ethanol
reagent
system.
a
short
time,
desired
selenylated
products
were
obtained
regioselectively
in
good
yields,
with
tolerance
wide
range
functional
groups.
The Chemical Record,
Journal Year:
2023,
Volume and Issue:
24(2)
Published: Sept. 5, 2023
Dihydroazolopyrimidines
are
an
important
class
of
heterocycles
that
isosteric
to
natural
purines
and
therefore
great
interest
primarily
as
drug-like
molecules.
In
contrast
the
heteroaromatic
analogs,
synthetic
approaches
these
compounds
were
developed
much
later,
their
chemical
properties
biological
activity
have
not
been
studied
in
detail
until
recently.
review,
different
ways
build
dihydroazolopyrimidine
systems
from
building
blocks
described
-
via
initial
formation
a
partially
hydrogenated
pyrimidine
ring
or
azole
ring,
well
one-pot
assembly
azine
fragments.
Special
attention
is
given
modern
approaches:
multicomponent
reactions,
green
chemistry,
use
non-classical
activation
methods.
Information
on
dihydroazolopyrimidines
prospects
for
design
drugs
various
profiles
also
summarized
this
review.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(5)
Published: Feb. 2, 2024
Abstract
A
practical
electrochemical
method
for
the
synthesis
of
β‐hydroxyselenides
has
been
developed
under
an
external
oxidant‐free
condition
at
room
temperature
air
from
alkenes
with
diselenides
and
H
2
O.
radical
mechanism
is
proposed
this
transformation
gram‐scale
reactions
demonstrate
practicability
reaction.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(4), P. 1998 - 1998
Published: Feb. 20, 2023
Dichalcogenides
(disulfides
and
diselenides),
as
reactants
for
organic
transformations,
are
important
widely
used
because
of
their
potential
to
react
with
nucleophiles,
electrophilic
reagents,
radical
precursors.
In
recent
years,
in
combination
photochemical
technology,
the
application
dichalcogenides
stable
reagents
has
opened
up
a
new
route
synthesis
various
sulfur-
selenium-containing
compounds.
this
paper,
synthetic
strategies
disulfides
diselenides
applications
technology
reviewed:
(i)
Cyclization
alkenes
alkynes;
(ii)
direct
selenylation/sulfuration
C−H/C−C/C−N
bonds;
(iii)
visible-light-enabled
seleno-
sulfur-bifunctionalization
alkenes/alkynes;
(iv)
Direct
construction
C(sp)–S
bond.
addition,
scopes,
limitations,
mechanisms
some
reactions
also
described.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 19, 2024
Abstract
Herein
we
report
for
the
first
time
a
sunlight‐driven,
irreversible
photocyclization
reaction
of
indole‐linked
trisubstituted
thiazoles,
synthesis
highly
fluorescent
thiazole‐fused
benzo[
]carbazoles
using
mixture
solvents
(CH
3
CN:
DMSO;
:
1).
Ring
opening
indole
moiety
was
observed
in
case
thiazole
derivatives
having
2‐methyl
substituents.
Under
similar
conditions,
thiazoles
cyclic
1,3‐dicarbonyls
place
also
worked.
This
provides
products
two
medicinally
important
moieties
and
benzocarbazoles.
We
have
studied
photophysical
properties
all
found
that
most
synthesized
very
good
fluorescence
quantum
yields.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(42), P. 8471 - 8476
Published: Jan. 1, 2023
A
visible
light
induced
C-3
thiocyanation
of
imidazo[1,2-a]pyridines
by
using
a
naphthalimide
based
photoredox
catalyst
has
been
reported.
Tolerance
electron
withdrawing
and
donating
groups
at
different
positions
the
imidazo[1,2-a]pyridine
ring
led
to
wide
substrate
accessibility
this
method.
This
methodology
is
further
reproducible
with
other
heterocycles
like
benzo[d]imidazo[2,1-b]thiazoles,
indoles,
azaindoles,
anilines.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(21), P. 13856 - 13872
Published: Oct. 10, 2022
A
dimethyl
sulfoxide-assisted
and
iodine/ascorbic
acid-catalyzed
simple
approach
to
pyrazolo[1,5-a]quinoline
thioether
derivatives
22
is
described.
The
compounds
were
identified
using
1H
NMR,
13C
high-resolution
mass
spectrometry,
single-crystal
X-ray
diffractometry.
was
synthesized
in
a
stepwise
fashion
through
aryl
sulfenylation
benzannulation
strategies.
generated
heteroaryl
23
exposed
the
path
produce
22.
reaction
proceeds
by
way
of
diazotization
pyrazole
amine
derivative
23,
radical
generation
removal
nitrogen,
eventually
trapping
with
support
phenylacetylene
19.
catalytic
amount
ascorbic
acid
aided
reaction.
There
several
other
control
studies
conducted,
including
reactions
isopropenyl
acetate,
tetramethylpiperidine
N-oxyl
reactions,
without
phenylacetylene.
Since
change
substitution
has
previously
demonstrated
substantial
bioactivity,
core
structure
evaluated
for
functional
group
tolerance.
reasonable
mechanism
then
proposed,
accompanied
experiments
scope.
Suzuki
used
create
an
aryl/heteroaryl
compound
35
from
one
22b.
In
controlled
oxidation
paths,
molecule
22a
selectively
transformed
into
corresponding
sulfoxide
32
sulfone
33.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(26), P. 4918 - 4922
Published: June 28, 2023
A
general
and
facile
approach
for
the
direct
oxidative
α-acyloxylation
of
ketones
using
molecular
oxygen
as
oxidant
is
developed.
This
method
avoids
use
excessive
peroxides
expensive
metal
catalysts,
affording
a
variety
α-acyloxylated
in
satisfactory
yields.
Experimental
studies
indicate
that
reaction
proceeds
via
radical
pathway.
Additionally,
α-hydroxy
could
be
obtained
by
changing
solvent.
Synthesis,
Journal Year:
2023,
Volume and Issue:
55(21), P. 3693 - 3699
Published: July 6, 2023
Abstract
A
new
method
has
been
developed
for
the
C–H
selenylation
of
pyrazolo[1,5-a]pyrimidine
derivatives
under
irradiation
visible
light.
This
photocatalyst-free
strategy
is
applicable
to
a
wide
range
pyrazolo[1,5-a]pyrimidines
with
broad
functionalities.
The
salient
features
are
mild
reaction
conditions,
use
bench-stable
oxidant,
high
regioselectivity,
and
scalability.
