European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
26(2)
Published: Dec. 2, 2022
Abstract
A
photochemical
method
based
on
visible‐light
(white
LEDs/sunlight)
irradiation
has
been
developed
for
the
regioselective
and
oxidative
C(sp
2
)−H
selenylation
sulfenylation
of
substituted
2‐amino‐1,4‐naphthoquinones
under
oxygen
atmosphere.
The
process
does
not
require
any
external
photoredox
catalysts.
other
notable
advantages
this
protocol
are
metal‐free
synthesis,
visible
light/sunlight
as
energy
sources,
good
substrate
scope,
moderate
to
yields
(41–91
%)
with
high
regioselectivity.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Jan. 1, 2025
Abstract
1,4‐Naphthoquinones
(1,4‐NQs)
are
an
important
class
of
molecules
with
diverse
pharmaceutical
applications.
Lawsone,
a
naturally
occurring
molecule
range
bioactivities,
falls
in
the
1,4‐NQs.
It
possesses
1,3‐dicarbonyl
functionality,
which
has
been
utilized
synthesis
bis‐lawsones
reaction
aldehydes.
In
this
review
we
have
discussed
notable
developments
bis‐lawsone
from
2009
to
2023.
Also,
highlights
limitations
and
future
perspectives
area.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(2), P. 1049 - 1060
Published: Jan. 4, 2023
A
straightforward
and
efficient
electrochemical
method
for
regioselective
C(sp2)-H
selenylation
sulfenylation
of
substituted
2-amino-1,4-naphthoquinones
has
been
unearthed.
This
oxidative
cross-coupling
reaction
avoids
using
transition
metal
catalysts,
oxidants,
high
temperatures.
The
other
notable
advantages
this
protocol
are
the
tolerance
diverse
functional
groups,
mild
conditions
at
ambient
temperature,
energy
efficiency,
good
to
excellent
yields,
short
times
(in
minutes),
gram-scale
applicability,
eco-friendliness.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(8)
Published: Jan. 19, 2024
Abstract
Over
the
past
few
years,
organic
chemistry
has
used
dye
rose
bengal‘s
ability
to
absorb
visible
light.
In
present‐day
research,
innovation
of
environmentally
friendly
processes
for
carbon‐carbon/carbon‐heteroatoms
(Nitrogen,
Oxygen,
Sulphur,
and
Phosphorus)
bond
formation
great
importance.
The
photocatalyzed
cross‐dehydrogenative
coupling
(CDC)
reactions
using
bengal
(RB)
is
a
promising
technique
creating
carbon‐carbon/carbon‐heteroatom
bonds
directly
from
readily
available
compounds.
Our
review
focuses
on
current
advancement
in
that
uses
bond‐making
synthesize
various
important
molecules
via
CDC
reactions.
New Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
46(28), P. 13483 - 13497
Published: Jan. 1, 2022
The
essence
of
photo-
and
electrochemistry:
sulfenylation
selenylation
substituted
benzo[
a
]phenazin-5-ols
through
cross-dehydrogenative
C(sp
2
)–H
functionalization.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(20), P. 3733 - 3738
Published: May 16, 2023
A
copper(II)-P,N,N-ligand
catalyzed
propargylic
[3
+
2]
cycloaddition
approach
for
the
synthesis
of
optically
enriched
dihydrofuro[3,2-c]coumarins
has
been
accomplished
first
time.
The
utilizes
esters
as
C2-bis-electrophiles
and
4-hydroxycoumarin
derivatives
C,O-bis-nucleophiles.
In
addition,
this
novel
strategy
was
also
explored
with
4-hydroxy-2-quinolinones
4-hydroxythiocoumarins.
Moreover,
various
their
quinolinone
thiocoumarin
analogues
were
synthesized
in
moderate
to
good
yields
high
enantioselectivities.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1645 - 1655
Published: Jan. 17, 2025
We
present
a
novel,
metal-
and
additive-free
method
for
the
robust
synthesis
of
dihydrofuran-fused
naphthalenes
coumarins.
This
approach
utilizes
annulative
coupling
sulfoxonium
ylides
with
aldehydes,
naphthols,
or
coumarins
at
ambient
temperature.
The
exhibits
broad
substrate
compatibility,
accommodating
various
functional
groups
on
naphthol
coumarin
derivatives
resulting
in
good
to
high
yields
desired
products.
Additionally,
we
successfully
scaled
up
reactions,
synthesized
were
further
converted
other
valuable
bioactive
molecules,
validating
viability
our
approach.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
88(1), P. 647 - 652
Published: Dec. 8, 2022
A
visible-light-induced
tandem
radical
brominative
addition/spiro-cyclization/1,2-ester
migration
of
activated
alkynes
with
CBr4
is
developed.
This
protocol
features
good
functional
group
tolerance,
operational
simplicity,
and
mild
reaction
conditions
without
the
use
catalysts
external
additives,
providing
easy
access
to
valuable
3-bromocoumarins
in
generally
high
yields.
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(63)
Published: Sept. 4, 2023
A
mechanochemistry-driven
practical
and
efficient
synthetic
protocol
for
accessing
diverse
series
of
biologically
relevant
poly-functionalized
5-(arylselanyl)-1H-1,2,3-triazoles
through
copper(I)-catalyzed
click
reaction
between
aryl/heteroaryl
acetylenes,
diaryl
diselenides,
benzyl
bromides,
sodium
azide
has
been
accomplished
under
high-speed
ball-milling.
Advantages
this
method
include
operational
simplicity,
avoidance
using
solvent
external
heating,
one-pot
synthesis,
short
time
in
minutes,
good
to
excellent
yields,
broad
substrate
scope,
gram-scale
applications.
Furthermore,
synthesized
organoselenium
compounds
were
synthetically
diversified
promising
selenones.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(15), P. 10524 - 10537
Published: July 19, 2024
We
herein
report
the
exploration
of
an
electrosynthetic
strategy
as
a
highly
efficient
and
straightforward
alternative
protocol
for
accessing
diversely
substituted
biologically
promising
alkyl
2-hydroxy-3-oxo-2,3-dihydrobenzofuran-2-carboxylates
through
electrorearranged
difunctionalization
4-hydroxycoumarins,
involving
singlet
oxygen
insertion
from
molecular
oxygen,
at
ambient
temperature.
The
present
method
is
notably
more
advantageous
than
previously
reported
photochemical
conversion
regarding
yields
reaction
times,
substrate
scope
functional
group
tolerability,
operational
simplicity,
scalability.
