Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(12), P. 2715 - 2720
Published: May 9, 2024
Abstract
A
one‐pot
multi‐component
reaction
strategy
for
the
selective
synthesis
of
5‐trifluoromethyl
pyrimidine
derivatives
has
been
established.
This
method
avoids
inherent
selectivity
challenges
in
direct
trifluoromethylation.
The
demonstrates
tolerance
to
various
functional
groups,
yielding
with
up
80%
yields.
Moreover,
practicality
this
underscored
through
scale‐up
reactions.
Mini-Reviews in Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
24(8), P. 793 - 843
Published: Sept. 14, 2023
Heterocyclic
derivatives
serve
as
the
fundamental
components
of
both
natural
and
synthetic
drugs.
Enaminones
play
a
crucial
role
foundational
units
in
synthesis
numerous
bioactive
heterocyclic
compounds,
including
pyrazoles,
pyridines,
oxazoles,
isoxazoles,
well
fused
structures
like
indoles,
carbazoles,
quinolines,
acridines,
phenanthridines.
These
diverse
rings
are
well-known
for
their
various
therapeutic
activities,
encompassing
anticancer,
anti-inflammatory,
antimicrobial,
antidepressant,
antiviral
properties.
By
reacting
with
nitrogenbased
nucleophiles,
enaminones
can
generate
azoles,
azines,
systems.
This
study
focuses
on
recent
advancements
enaminone
reactions
(a)
nitrogen-based
such
aliphatic
amines,
aniline,
hydroxylamine,
hydrazine
derivatives,
guanidine
urea,
thiourea
(b)
electrophiles,
diazonium
salts.
have
led
to
wide
range
compounds
from
2010
end
2022.
The Chemical Record,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Abstract
Selectfluor,
[1‐chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo[2.2.2]octane
bis(tetrafluoroborate)],
is
a
highly
valuable
reagent
in
contemporary
chemistry,
serving
not
only
as
an
electrophilic
fluorinating
agent
but
also
effective
catalyst
the
synthesis
of
various
pharmaceutically
relevant
heterocycles.
This
review
article
seeks
to
present
comprehensive
overview
significant
heterocyclic
ring
formations
facilitated
by
selectfluor.
Both
metal‐free
and
metal‐catalyzed
recent
advancement
on
selectfluor
mediated
cyclisation
processes
are
discussed
this
mainly
over
last
eight
years
(2017‐April
2024).
A
novel
one-pot
oxidative
cross-dehydrogenation
coupling
(CDC)
reaction
has
been
developed
for
the
selective
construction
of
C–N
and
C–C
bonds
at
C2,3-positions
indoles.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
The
green
and
sustainable
electrochemical
oxidative
cyclization
of
enaminones
with
p-methoxy/p-hydroxy
anilines
has
been
developed,
enabling
the
regioselective
synthesis
indoles
benzofurans.
methods
are
significant
advantage
not
only
due
to
mild
metal-free
conditions,
but
also
because
employment
easily
available
stable
aniline
substrates
replace
unstable
quinoneimide
for
a
similar
annulation
in
previous
work.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(36), P. 7138 - 7150
Published: Jan. 1, 2022
This
review
systematically
summarizes
for
the
first
time
recent
developments
in
3-aminoindazoles
as
versatile
synthons
to
construct
nitrogen
heterocycles
through
condensation
annulation,
denitrogenative
transannulation
and
rearrangement
ring
expansion.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(21), P. 13708 - 13714
Published: Sept. 30, 2022
We
have
developed
a
Diels
Alder
cycloaddition
route
toward
3-aroyl
quinolines
from
enaminones
and
in
situ
generated
aza-o-quinone
methides.
The
reaction
was
found
to
be
general
with
range
of
substituted
methides,
we
could
validate
the
applicability
methodology
gram
scale.
also
demonstrated
one-pot
strategy
3-acyl
starting
corresponding
aliphatic
ketones.
Finally,
utilized
for
synthesizing
indeno[1,2-b]quinolinones
via
Pd-catalyzed
dual
C–H
activation
approach.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(43)
Published: Aug. 3, 2024
Abstract
Fused
pyrimidines
are
a
class
of
heterocyclic
compounds
that
have
gained
considerable
interest
due
to
their
extensive
biological
activities
and
potential
applications
in
drug
development.
This
review
article
aims
provide
comprehensive
overview
the
latest
synthetic
approaches
fused
pyrimidines,
including
Michael
reactions,
multicomponent
metal‐catalyzed
photocatalytic
peroxide‐mediated
inverse
electron
demand
Diels–Alder
reactions.
Furthermore,
these
compounds,
such
as
ability
combat
cancer
microbial
infections,
also
discussed.
summarizes
existing
literature
on
synthesis
activity
from
2020
2023.
We
hope
this
will
inspire
development
more
effective
less
toxic
pyrimidine
drugs
with
well‐designed
structures.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
first
synthesis
of
3,4-diarylpyrimido[1,2-
b
]indazole
derivatives
enabled
by
the
epoxide-opening
reaction
with
3-aminoindazoles
has
been
realized.
