Pd(II)‐Catalyzed Site‐Selective Cross Coupling Reaction: Synthesis of Highly Fluorescent Aryl−Formyl−Chromenes and its Iminoantipyrine Analogues as Selective AChE Inhibitors DOI
Grace Victoria Govada,

Sanjivani Pal,

Paranimuthu Panjacharam

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(8)

Published: July 3, 2024

A versatile and efficient chemo selective synthesis of 4-aryl-3-formyl-2H-chromenes (AFC) was undertaken using Pd-catalyzed cross-coupling conditions. The key oxidative transmetalation successfully applied to a significant range substitutions on the chromene moiety aryl ring in Ar(BOH)

Language: Английский

Highlighting multicomponent reactions as an efficient and facile alternative route in the chemical synthesis of organic-based molecules: a tremendous growth in the past 5 years DOI Creative Commons
Reagan L. Mohlala, Thompho Jason Rashamuse,

E. Mabel Coyanis

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 18, 2024

Since Strecker’s discovery of multicomponent reactions (MCRs) in 1850, the strategy applying an MCR approach has been use for over a century. Due to their ability quickly develop molecular diversity and structural complexity interest, MCRs are considered efficient organic synthesis. Although such as Ugi, Passerini, Biginelli, Hantzsch widely studied, this review emphasizes significance selective elegantly produce compounds potential medicinal chemistry industrial material science applications, well sustainable methods. During synthesis, provide advantages atom economy, recyclable catalysts, moderate conditions, preventing waste, avoiding solvent use. also reduce number sequential multiple one step.

Language: Английский

Citations

7
Synthesis, crystal structure, Hirshfeld surface analysis, DFT investigation, and molecular docking, of novel organic dithiocarbamates obtained from Baylis-Hillman adducts/alcohols at room temperature DOI
Vishal Prasad Sharma,

Vipin Kumar,

Rashmi Singh

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1305, P. 137715 - 137715

Published: Feb. 4, 2024

Language: Английский

Citations

6
S-alkyl Dithiocarbamates Synthesis through Electrochemical Multicomponent Reaction of Thiols, Hydrogen Sulfide, and Isocyanides DOI
Xiaoying Liu,

Tian-Cheng Cai,

Mengxue Zhu

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(17), P. 12311 - 12318

Published: Aug. 16, 2023

Dithiocarbamates synthesis is extremely important in plenty of biomedical and agrochemical applications, especially fungicide development, but remains a great challenge. In this work, we have successfully developed multicomponent reaction protocol to convert H2S into S-alkyl dithiocarbamates under constant current conditions. No additional oxidants nor catalysts are required, due mild conditions, the reactions display broad substrate scope, including varieties thiols or disulfides.

Language: Английский

Citations

11
Electro-Oxidative Three-Component Synthesis of 3,5-Disubstituted-1,2,4-Thiadiazoles from Amines, Amidines, and CS2 DOI
Peng‐Fei Huang, Ying Peng,

Jia-Le Fu

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

1,2,4-Thiadiazoles, a significant class of heterocyclic compounds, are widely found in biologically active molecules. Herein, we report green electrochemical three-component reaction amines, amidines, and CS2 for the effective synthesis 3,5-disubstituted-1,2,4-thiadiazoles under metal- oxidant-free conditions. Both aliphatic aryl amines well-tolerated at room temperature simple undivided cell. A series 1,2,4-thiadiazoles prepared with excellent functional groups.

Language: Английский

Citations

0
Synthesis of S-aryl dithiocarbamates and its in-silico studies DOI Creative Commons
Kartiki V. Desai,

M. V. Santhosh,

Padmanaban Akashvarunan

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102257 - 102257

Published: April 1, 2025

Language: Английский

Citations

0
Visible Light-Mediated Carbamoylation of para-Quinone Methides DOI
Tavinder Singh,

Ganesh Chandra Upreti,

Shivani Arora

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(5), P. 2784 - 2791

Published: Feb. 15, 2023

We report a photocatalytic approach for the installation of amide moiety onto para-quinone methides. This transformation features net reductive generation carbamoyl radicals from amide-substituted Hantzsch ester derivatives under transition metal-free conditions. protocol exhibits wide scope and allows access to diarylacetamides employing C-C bond formation approach.

Language: Английский

Citations

9
Synthesis of S-Alkyl Dithiocarbamates via Multicomponent Reaction of Cyclic Sulfonium Salts with CS2 and Amines DOI

Li Yang,

Jia Shu, Yun Liu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

A convenient and practical method for the synthesis of various

Language: Английский

Citations

3
Synthesis of Functionalized Thioimidates from Thioamides and Arylboronic Acids via Copper-Catalyzed Cross-Coupling Reaction at Room Temperature DOI
Nitin Kumar, Sundaram Singh, Jeyakumar Kandasamy

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Functionalized S-aryl thioimidates were synthesized from thioamides and arylboronic acids at room temperature under mild conditions. The reaction was catalyzed by copper(II) acetate in the presence of DBU an open atmosphere. A wide range functionalized aryl alkyl boronic chemo-selectively coupled with to obtain corresponding S-alkyl 64–80% yields. Room reactions, easy operation, broad substrate scope are salient features developed methodology.

Language: Английский

Citations

0
Biocompatible C-S bond construction for diarylmethyl thioethers DOI Creative Commons
Zhenwei Zhang, Tao Xu,

C. Ju

et al.

Green Synthesis and Catalysis, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Synthesis of functionalized S-benzyl dithiocarbamates from diazo-compounds via multi-component reactions with carbon disulfide and secondary amines DOI
Nitin Kumar, Rapelly Venkatesh, Jeyakumar Kandasamy

et al.

Organic & Biomolecular Chemistry, Journal Year: 2022, Volume and Issue: 20(34), P. 6766 - 6770

Published: Jan. 1, 2022

Triflic acid promoted multicomponent synthesis of functionalized S -benzyl dithiocarbamates from diazo compounds and secondary amines in the presence carbon disulfide is described.

Language: Английский

Citations

14