Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
20(8)
Published: July 7, 2023
Abstract
An
efficient
metal‐free
approach
for
site
selective
C−N
coupling
reaction
of
benzo[d]isoxazole
and
2
H
‐chromene
derivatives
has
been
designed
developed
against
AchE.
This
nitrogen
containing
organo‐base
promoted
methodology,
which
is
both
practical
environmentally
friendly,
provides
an
easy
suitable
pathway
synthesizing
Benzisoxazole‐Chromene
(BC)
possessing
poly
heteroaryl
moieties.
The
synthesized
BC
4
a
–
n
was
docked
into
the
active
sites
AChE
to
obtain
more
perception
binding
modes
compounds.
Out
them,
compound
l
displayed
potent
activity
high
selectivity
inhibition.
Final
docking
results
indicates
that
showed
lowest
energy
−11.2260
kcal/mol
with
AChE.
analogs
would
be
potential
candidates
promoting
studies
in
medicinal
chemistry
research.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Sept. 18, 2024
Since
Strecker’s
discovery
of
multicomponent
reactions
(MCRs)
in
1850,
the
strategy
applying
an
MCR
approach
has
been
use
for
over
a
century.
Due
to
their
ability
quickly
develop
molecular
diversity
and
structural
complexity
interest,
MCRs
are
considered
efficient
organic
synthesis.
Although
such
as
Ugi,
Passerini,
Biginelli,
Hantzsch
widely
studied,
this
review
emphasizes
significance
selective
elegantly
produce
compounds
potential
medicinal
chemistry
industrial
material
science
applications,
well
sustainable
methods.
During
synthesis,
provide
advantages
atom
economy,
recyclable
catalysts,
moderate
conditions,
preventing
waste,
avoiding
solvent
use.
also
reduce
number
sequential
multiple
one
step.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Functionalized
S-aryl
thioimidates
were
synthesized
from
thioamides
and
arylboronic
acids
at
room
temperature
under
mild
conditions.
The
reaction
was
catalyzed
by
copper(II)
acetate
in
the
presence
of
DBU
an
open
atmosphere.
A
wide
range
functionalized
aryl
alkyl
boronic
chemo-selectively
coupled
with
to
obtain
corresponding
S-alkyl
64–80%
yields.
Room
reactions,
easy
operation,
broad
substrate
scope
are
salient
features
developed
methodology.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
1,2,4-Thiadiazoles,
a
significant
class
of
heterocyclic
compounds,
are
widely
found
in
biologically
active
molecules.
Herein,
we
report
green
electrochemical
three-component
reaction
amines,
amidines,
and
CS2
for
the
effective
synthesis
3,5-disubstituted-1,2,4-thiadiazoles
under
metal-
oxidant-free
conditions.
Both
aliphatic
aryl
amines
well-tolerated
at
room
temperature
simple
undivided
cell.
A
series
1,2,4-thiadiazoles
prepared
with
excellent
functional
groups.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(5), P. 2784 - 2791
Published: Feb. 15, 2023
We
report
a
photocatalytic
approach
for
the
installation
of
amide
moiety
onto
para-quinone
methides.
This
transformation
features
net
reductive
generation
carbamoyl
radicals
from
amide-substituted
Hantzsch
ester
derivatives
under
transition
metal-free
conditions.
protocol
exhibits
wide
scope
and
allows
access
to
diarylacetamides
employing
C-C
bond
formation
approach.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(17), P. 12311 - 12318
Published: Aug. 16, 2023
Dithiocarbamates
synthesis
is
extremely
important
in
plenty
of
biomedical
and
agrochemical
applications,
especially
fungicide
development,
but
remains
a
great
challenge.
In
this
work,
we
have
successfully
developed
multicomponent
reaction
protocol
to
convert
H2S
into
S-alkyl
dithiocarbamates
under
constant
current
conditions.
No
additional
oxidants
nor
catalysts
are
required,
due
mild
conditions,
the
reactions
display
broad
substrate
scope,
including
varieties
thiols
or
disulfides.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(37)
Published: Aug. 2, 2023
Abstract
An
efficient
and
eco‐friendly
method
has
been
developed
for
the
preparation
of
functionalized
3‐(
S
)‐arylthioindoles
in
good
to
excellent
yields
from
indoles
aryl
thiols
water.
The
coupling
reaction
was
prompted
by
K
2
O
8
presence
glucose
at
room
temperature.
Broad
substrate
scope,
functional
group
tolerance,
temperature
reactions
metal‐free
conditions
are
salient
features
methodology.
