Crystal structure of (2S,3S,4S,5S, Z)-2,3,5,6-tetrakis(benzyloxy)-4-hydroxyhexanal oxime, C34H37NO6 DOI Creative Commons

Nuo Zhang,

Shuo-Nan Guo,

Liang-Qi Du

et al.

Zeitschrift für Kristallographie - New Crystal Structures, Journal Year: 2023, Volume and Issue: 238(6), P. 1035 - 1037

Published: Sept. 14, 2023

Abstract C 34 H 37 NO 6 , triclinic, P 1̄ (no. 2), a = 6.398(6) Å, b 10.779(10) c 12.030(11) α 71.103(10)°, β 89.519(11)°, γ 74.154(11)°, V 752.2(12) Å 3 Z 1, R gt (F) 0.0599, wR ref (F 2 ) 0.1614, T 296 K.

Language: Английский

Some pyrroles as inhibitors of the pentose phosphate pathways enzymes: An in vitro and molecular docking study DOI
Muhammet Serhat Özaslan

Journal of Molecular Recognition, Journal Year: 2024, Volume and Issue: 37(3)

Published: March 21, 2024

Abstract Glucose‐6‐phosphate dehydrogenase (G6PD) and 6‐phosphogluconate (6PGD) are pentose phosphate pathway enzymes. Compounds with a heterocyclic pyrrole ring system containing this atom can be derivatized various functional groups into highly effective bioactive agents. In study, derivatives on these enzyme's activity were investigated. The IC 50 values of different concentrations for G6PD found in the range 0.022–0.221 mM K i 0.021 ± 0.003–0.177 6PGD 0.020–0.147, 0.013 0.002–0.113 0.030 mM. 2‐acetyl‐1‐methylpyrrole ( 1g ) showed best inhibition value addition, silico molecular docking experiments performed to elucidate how 1a – g interact binding sites target study's findings could used create innovative therapeutics that treatment many diseases, especially cancer manifestations.

Language: Английский

Citations

1
Borylated Monosaccharide 3-Boronic-3-deoxy-d-galactose: Detailed NMR Spectroscopic Characterisation, and Method for Spectroscopic Analysis of Anomeric and Boron Equilibria DOI Open Access
Michela I. Simone

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12396 - 12396

Published: Nov. 19, 2024

Drug leads with a high Fsp

Language: Английский

Citations

1
trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease DOI Creative Commons

Jun-Zhe Wang,

Yuna Shimadate,

Maki Kise

et al.

European Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 238, P. 114499 - 114499

Published: May 29, 2022

Language: Английский

Citations

6
C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study DOI
Yi‐Xian Li,

Jun-Zhe Wang,

Yuna Shimadate

et al.

European Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 244, P. 114852 - 114852

Published: Oct. 21, 2022

Language: Английский

Citations

4
Multicomponent Reactions for the Synthesis of Natural Products and Natural Product-Like Libraries DOI
M.J. Ruiz-Serrano, J. Carlos Menéndez

Published: Jan. 1, 2023

Multicomponent reactions involve at least three starting materials that are combined in a single operation and convergent, atom-economic, step-efficient. They provide highly efficient alternative to sequential multistep procedures therefore ideally suited for simplifying target-oriented synthetic efforts. In this context, chapter reviews the use of multicomponent as key step natural product synthesis.

Language: Английский

Citations

1
Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-l-rhamnosidase: design, synthesis and structure-activity relationship study DOI

Feng-Teng Gao,

Min Zhang,

Yuna Shimadate

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 282, P. 117031 - 117031

Published: Nov. 12, 2024

Language: Английский

Citations

0
Recent synthetic strategies to access diverse iminosugars DOI
Camilla Matassini, Francesca Cardona

Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 335 - 364

Published: Oct. 27, 2023

Language: Английский

Citations

0
Crystal structure of (2S,3S,4S,5S, Z)-2,3,5,6-tetrakis(benzyloxy)-4-hydroxyhexanal oxime, C34H37NO6 DOI Creative Commons

Nuo Zhang,

Shuo-Nan Guo,

Liang-Qi Du

et al.

Zeitschrift für Kristallographie - New Crystal Structures, Journal Year: 2023, Volume and Issue: 238(6), P. 1035 - 1037

Published: Sept. 14, 2023

Abstract C 34 H 37 NO 6 , triclinic, P 1̄ (no. 2), a = 6.398(6) Å, b 10.779(10) c 12.030(11) α 71.103(10)°, β 89.519(11)°, γ 74.154(11)°, V 752.2(12) Å 3 Z 1, R gt (F) 0.0599, wR ref (F 2 ) 0.1614, T 296 K.

Language: Английский

Citations

0