Some pyrroles as inhibitors of the pentose phosphate pathways enzymes: An in vitro and molecular docking study
Journal of Molecular Recognition,
Journal Year:
2024,
Volume and Issue:
37(3)
Published: March 21, 2024
Abstract
Glucose‐6‐phosphate
dehydrogenase
(G6PD)
and
6‐phosphogluconate
(6PGD)
are
pentose
phosphate
pathway
enzymes.
Compounds
with
a
heterocyclic
pyrrole
ring
system
containing
this
atom
can
be
derivatized
various
functional
groups
into
highly
effective
bioactive
agents.
In
study,
derivatives
on
these
enzyme's
activity
were
investigated.
The
IC
50
values
of
different
concentrations
for
G6PD
found
in
the
range
0.022–0.221
mM
K
i
0.021
±
0.003–0.177
6PGD
0.020–0.147,
0.013
0.002–0.113
0.030
mM.
2‐acetyl‐1‐methylpyrrole
(
1g
)
showed
best
inhibition
value
addition,
silico
molecular
docking
experiments
performed
to
elucidate
how
1a
–
g
interact
binding
sites
target
study's
findings
could
used
create
innovative
therapeutics
that
treatment
many
diseases,
especially
cancer
manifestations.
Language: Английский
Borylated Monosaccharide 3-Boronic-3-deoxy-d-galactose: Detailed NMR Spectroscopic Characterisation, and Method for Spectroscopic Analysis of Anomeric and Boron Equilibria
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12396 - 12396
Published: Nov. 19, 2024
Drug
leads
with
a
high
Fsp
Language: Английский
trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease
Jun-Zhe Wang,
No information about this author
Yuna Shimadate,
No information about this author
Maki Kise
No information about this author
et al.
European Journal of Medicinal Chemistry,
Journal Year:
2022,
Volume and Issue:
238, P. 114499 - 114499
Published: May 29, 2022
Language: Английский
C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study
Yi‐Xian Li,
No information about this author
Jun-Zhe Wang,
No information about this author
Yuna Shimadate
No information about this author
et al.
European Journal of Medicinal Chemistry,
Journal Year:
2022,
Volume and Issue:
244, P. 114852 - 114852
Published: Oct. 21, 2022
Language: Английский
Multicomponent Reactions for the Synthesis of Natural Products and Natural Product-Like Libraries
Published: Jan. 1, 2023
Multicomponent
reactions
involve
at
least
three
starting
materials
that
are
combined
in
a
single
operation
and
convergent,
atom-economic,
step-efficient.
They
provide
highly
efficient
alternative
to
sequential
multistep
procedures
therefore
ideally
suited
for
simplifying
target-oriented
synthetic
efforts.
In
this
context,
chapter
reviews
the
use
of
multicomponent
as
key
step
natural
product
synthesis.
Language: Английский
Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-l-rhamnosidase: design, synthesis and structure-activity relationship study
Feng-Teng Gao,
No information about this author
Min Zhang,
No information about this author
Yuna Shimadate
No information about this author
et al.
European Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
282, P. 117031 - 117031
Published: Nov. 12, 2024
Language: Английский
Recent synthetic strategies to access diverse iminosugars
Elsevier eBooks,
Journal Year:
2023,
Volume and Issue:
unknown, P. 335 - 364
Published: Oct. 27, 2023
Language: Английский
Crystal structure of (2S,3S,4S,5S, Z)-2,3,5,6-tetrakis(benzyloxy)-4-hydroxyhexanal oxime, C34H37NO6
Nuo Zhang,
No information about this author
Shuo-Nan Guo,
No information about this author
Liang-Qi Du
No information about this author
et al.
Zeitschrift für Kristallographie - New Crystal Structures,
Journal Year:
2023,
Volume and Issue:
238(6), P. 1035 - 1037
Published: Sept. 14, 2023
Abstract
C
34
H
37
NO
6
,
triclinic,
P
1̄
(no.
2),
a
=
6.398(6)
Å,
b
10.779(10)
c
12.030(11)
α
71.103(10)°,
β
89.519(11)°,
γ
74.154(11)°,
V
752.2(12)
Å
3
Z
1,
R
gt
(F)
0.0599,
wR
ref
(F
2
)
0.1614,
T
296
K.
Language: Английский