Unprecedented synthesis of indole-linked tetra-substituted alkenes by catalyst-free domino reaction DOI

Darakshan,

Ujjain Chaurasia,

Aatka Mehar

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134327 - 134327

Published: Oct. 1, 2024

Language: Английский

Electrochemical Enaminone-Thioamide Annulation and Thioamide Dimeric Annulation for the Tunable Synthesis of Thiazoles and 1,2,4-Thiadiazole DOI

Qihui Huang,

Jianchao Liu, Jie‐Ping Wan

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(25), P. 5263 - 5268

Published: June 14, 2024

A green and sustainable electrochemical oxidative cyclization of enaminones with thioamides under metal- oxidant-free conditions has been developed, providing an efficient approach for thiazole synthesis. Furthermore, 1,2,4-thiadiazoles can be selectively accessed via the dimerization in absence enaminones.

Language: Английский

Citations

17
Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 MPro and PLPro DOI Open Access
Hossein Mousavi, Behzad Zeynizadeh, Mehdi Rimaz

et al.

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 135, P. 106390 - 106390

Published: Jan. 28, 2023

Language: Английский

Citations

27
Recent advances in spirocyclization of maleimides via transition-metal catalyzed C–H activation DOI
Swadhin Swaraj Acharya,

Sagarika Patra,

Rojalini Maharana

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(15), P. 2916 - 2947

Published: Jan. 1, 2024

In recent years, the maleimide scaffold has received a great deal of attention in C–H activation.

Language: Английский

Citations

15
Iodine-Promoted Thioylation and Dicarbonylation of Enaminone α-C Sites: Synthesis of Fully Substituted Thiazoles via C═C Bond Cleavage DOI
Peng Zhao, You Zhou, Can Wang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(4), P. 2505 - 2515

Published: Feb. 5, 2024

A novel iodine-promoted difunctionalization of α-C sites in enaminones was demonstrated as a means synthesizing variety fully substituted thiazoles by constructing C–C(CO), C–S, and C–N bonds. This transformation allows the realization unusual aryl C2 synthons simultaneously thioylation dicarbonylation sites. preliminary mechanistic study performed indicated that cleavage C═C bonds involves bicyclization/ring-opening oxidative coupling sequence.

Language: Английский

Citations

14
HFIP-Mediated Multicomponent Reactions: Synthesis of Pyrazole-Linked Thiazole Derivatives DOI

Riddhiman Banerjee,

Danish Ali,

Nurabul Mondal

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(7), P. 4423 - 4437

Published: March 14, 2024

The development of one-pot, atom, and step-economic new methods avoiding metal, harsh reaction conditions, toxic reagents for the synthesis medicinally important hybrid molecules bearing more than one bioactive moieties is currently hot topics in organic synthesis. Herein, we report a green efficient room temperature multicomponent novel pyrazole-linked thiazoles involving one-pot C–C, C–N, C–S bond-forming process from aryl glyoxal, thioamide, pyrazolones 1,1,1,3,3,3-hexafluoroisopropanol, hydrogen bond donating medium. A set diverse thiazole pyrazole were prepared good to excellent yields by using this method. This methodology can also be extended prepare thiazole-linked barbiturates as well imidazole-linked pyrazoles. All products fully characterized spectroscopic techniques. notable features protocol are temperature, metal additive-free use recyclable solvent, water byproduct, wide substrate scope, operational simplicity, easy purification, applicability gram-scale synthesis, high atom economy, presence two products.

Language: Английский

Citations

10
Pseudo‐Multicomponent Reactions of Lawsone: Synthetic Strategies of Bis‐Lawsone DOI Open Access
Swadhin Swaraj Acharya,

Dibyaranjan Samantaray,

Chipuru Sibakrishna

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract 1,4‐Naphthoquinones (1,4‐NQs) are an important class of molecules with diverse pharmaceutical applications. Lawsone, a naturally occurring molecule range bioactivities, falls in the 1,4‐NQs. It possesses 1,3‐dicarbonyl functionality, which has been utilized synthesis bis‐lawsones reaction aldehydes. In this review we have discussed notable developments bis‐lawsone from 2009 to 2023. Also, highlights limitations and future perspectives area.

Language: Английский

Citations

1
Humic Acid: A Promising and Green Bioorganic Catalyst in Organic Syntheses DOI
Swadhin Swaraj Acharya, Bibhuti Bhusan Parida

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(12)

Published: March 25, 2024

Abstract The growing pollution and threat to the environment demand green synthetic methods. Green chemistry mainly focuses on minimizing waste utilization of solvents, energy sources, catalysts prefers one‐pot reactions. In this context, humic acid (HA), a natural bioorganic catalyst found in rivers, peat coal sewage; is high molecular weight macromolecule containing multifunctional groups, contains quinone, phenolic OH, COOH groups which make it acidic activate carbonyl by protonation. Owing its aspect such as biodegradability, recyclability reusability, considered sustainable meets criteria for industrial requirements. HA mild nature, thus many functional tolerate catalyzed After few initial reports 2001 2009, reactions gained much attention organic community from 2019 aldol condensation, Knoevenagel Claisen‐Schmidt reaction, Michael addition, Strecker synthesis, tetrazole Hantzsch dihydropyridine hydrosilylation terminal alkenes, hydrogenation, α ‐aminophosphonate cross coupling Heck Suzuki Herein we report comprehensive analysis role transformations providing diverse array scaffolds till date future perspective.

Language: Английский

Citations

7
Simple and efficient synthesis of novel thiazolo[4,5-e]indole derivatives via three-component reaction DOI

Bing-Wei Wang,

Meilan Huang, Xue Wang

et al.

Journal of Chemical Sciences, Journal Year: 2025, Volume and Issue: 137(1)

Published: Jan. 29, 2025

Language: Английский

Citations

0
One-Pot Multicomponent Synthesis of Fully Substituted 1,3-Thiazoles Appended with Naturally Occurring Lawsone DOI
Swadhin Swaraj Acharya,

Bisal Kumar Guin,

Bibhuti Bhusan Parida

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Lawsone is a popular bioactive natural product. 1,3-Thiazoles are also widely distributed in many products, FDA-approved drugs, and functional materials. We report herein the first synthesis of naturally occurring lawsone-linked fully substituted 1,3-thiazoles one-pot multicomponent reaction (MCR) arylglyoxals, lawsone, thiobenzamides acetic acid at 90 °C, affording lawsone-1,3-thiazole hybrids excellent yields short times. The advantages present method include facile, robust, easy access to medicinally relevant diverse array hybrids, isolation product by filtration, thereby avoiding column-chromatographic purifications, time, metal- catalyst-free gram-scale synthesis.

Language: Английский

Citations

0
Advances in Organic Synthesis and Properties Based On Tetraphenylimidazole Derivatives DOI
Hui‐Bin Huang, Yang Li, Can Zeng

et al.

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations

0