LiBr-Promoted Reaction of β-Ketodithioesters and Thioamides with Sulfoxonium Ylides to Synthesize Functionalized Thiophenes DOI
Subhasish Ray, Neetu Gupta, Maya Shankar Singh

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(43), P. 9401 - 9406

Published: Oct. 22, 2024

An operationally simple and highly efficient synthesis of functionalized thiophenes has been developed by LiBr promoted heteroannulation β-ketodithioesters thioamides with bench-stable sulfoxonium ylides in open air for the first time. This one-pot strategy involves formal Csp3–H bond insertion/intramolecular cyclization cascade, featuring readily accessible starting materials, TM additive-free condition, broad substrate scope, high functional group compatibility, scalability. Moreover, carbonyl, thiomethyl, amino groups resulting thiophene provide a good handle on downstream transformations.

Language: Английский

Ru-catalyzed C–H activation/cyclization of oximes with sulfoxonium ylides to access isoquinolines DOI

Darun Yang,

Hongyan Xu,

Xuejun Zhang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(33), P. 6750 - 6756

Published: Jan. 1, 2023

An external oxidant free Ru(II)-catalyzed C-H activation followed by an intermolecular annulation between oximes and sulfoxonium ylides has been developed. This transformation proceeds smoothly with a broad range of substrates, affording series isoquinoline derivatives in moderate to good yields. protocol was successfully applied the synthesis moxaverine.

Language: Английский

Citations

3
Redox-neutral access to isoquinolines via cobalt(III)-catalyzed C H acylmethylation/cyclization of benzimidates with sulfoxonium ylides DOI
Min Li, Zhenhai Xia,

Lixing Tang

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 146, P. 155185 - 155185

Published: July 7, 2024

Language: Английский

Citations

0
A rhodium-catalyzed C‒H activation/cyclization approach toward the total syntheses of cassiarin C and 8-O-methylcassiarin A from a common intermediate DOI
Didier F. Vargas, Santiago Fonzo, Sebastián O. Simonetti

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(38), P. 7880 - 7894

Published: Jan. 1, 2024

Three short and efficient total syntheses of cassiarin C are reported, from a chromanone common key intermediate. A C-H activation strategy, under rhodium catalysis on its pivaloyl oxime, enabled the installation pyridine ring. Dehydrogenation 8-

Language: Английский

Citations

0
Ru-Catalyzed Ortho C–H Alkylation of 4-Aryl-pyrrolo[2,3-d]pyrimidines with Diazo Compounds: An Access to Fluorescent Fused Heteroarenes DOI
Jiangrong Wang, Chunfeng Li,

Chunwei Shen

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

A Ru(II)-catalyzed migratory insertion of carbene into

Language: Английский

Citations

0
Identification of novel 3-aryl-1-aminoisoquinolines-based KRASG12C inhibitors: Rational drug design and expedient construction by C H functionalization/annulation DOI

Zi‐Rong Gong,

Yu Zhao,

Buyi Xu

et al.

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 142, P. 106954 - 106954

Published: Nov. 2, 2023

Language: Английский

Citations

1
LiBr-Promoted Reaction of β-Ketodithioesters and Thioamides with Sulfoxonium Ylides to Synthesize Functionalized Thiophenes DOI
Subhasish Ray, Neetu Gupta, Maya Shankar Singh

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(43), P. 9401 - 9406

Published: Oct. 22, 2024

An operationally simple and highly efficient synthesis of functionalized thiophenes has been developed by LiBr promoted heteroannulation β-ketodithioesters thioamides with bench-stable sulfoxonium ylides in open air for the first time. This one-pot strategy involves formal Csp3–H bond insertion/intramolecular cyclization cascade, featuring readily accessible starting materials, TM additive-free condition, broad substrate scope, high functional group compatibility, scalability. Moreover, carbonyl, thiomethyl, amino groups resulting thiophene provide a good handle on downstream transformations.

Language: Английский

Citations

0