Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
13(3)
Published: Dec. 16, 2023
Abstract
A
Lewis
base
catalyzed
C−S
bond
formation
through
thiocyanation
of
methyl
C(sp
3
)−H
is
reported.
The
method
involves
a
sequential
chlorination
and
reaction.
This
simple
yet
effective
protocol
works
with
diverse
array
indoles
to
furnish
thiocyanated
products
in
good
yield
(up
85
%).
developed
also
applied
for
the
synthesis
phercaptoline
(hypotensive
agent)
umifenovir
(antiviral
drug).
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
11(2), P. 597 - 630
Published: Nov. 23, 2023
This
review
highlights
the
recent
progress
in
electrochemical
difunctionalization
of
alkenes
and
alkynes
involving
C–S/Se
bond
formation
to
access
organochalcogen
frameworks.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(7), P. 4833 - 4838
Published: March 22, 2023
A
facile
and
practical
method
for
the
synthesis
of
fused
tricyclic
pyrazolo[5,1-a]isoquinolines
has
been
realized
via
reactions
enaminones,
hydrazine
hydrochloride,
internal
alkynes.
By
means
Rh
catalysis,
extraordinary
high-order
bond
functionalization,
including
transformation
aryl
C–H,
ketone
C═O,
alkenyl
C–N
bonds
in
marks
major
feature
cascade
reactions.
The
results
disclose
individual
advantage
enaminones
design
novel
efficient
synthetic
methods.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(25), P. 5263 - 5268
Published: June 14, 2024
A
green
and
sustainable
electrochemical
oxidative
cyclization
of
enaminones
with
thioamides
under
metal-
oxidant-free
conditions
has
been
developed,
providing
an
efficient
approach
for
thiazole
synthesis.
Furthermore,
1,2,4-thiadiazoles
can
be
selectively
accessed
via
the
dimerization
in
absence
enaminones.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(12), P. 4656 - 4661
Published: Jan. 1, 2023
An
electrochemical-enabled
three-component
cascaded
cyclization
of
enaminones
with
potassium
thiocyanate
and
alcohols
to
access
2-alkoxythiazoles
has
been
developed
under
external
oxidant-free
conditions.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(45), P. 6885 - 6888
Published: Jan. 1, 2023
The
annulation
reactions
of
enaminones
with
quinonediimides/quinoneimides
for
the
selective
synthesis
indoles
and
2-aminobenzofurans
have
been
realized.
With
Zn(II)
catalysis,
quinonediimides
reacted
to
give
via
HNMe2-elimination-based
aromatization.
Fe(III)
quinoneimides
provided
a
key
dehydrogenative
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(15), P. 11060 - 11066
Published: July 24, 2024
Reported
herein
is
a
new
photocatalytic
annulation
for
the
synthesis
of
2,3,4,6-tetrasubstituted
pyridines
with
enaminones
and
N,N,N′,N′-tetramethyl
ethylenediamine
(TMEDA).
The
reactions
take
place
without
requiring
transition
metal
reagent
provide
products
broad
scope.
methyl
in
TMEDA
acts
as
carbon
source
pyridine
ring
construction,
BrCF2CO2Et
plays
role
terminal
oxidant
free
radical
quenching.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(7), P. 1649 - 1653
Published: Feb. 7, 2024
Abstract
An
I
2
‐promoted
[3+2]
cyclization
reaction
between
thiocarbamates
with
enaminones
has
been
developed
for
the
synthesis
of
thiazol‐2(3
H
)‐one
derivatives.
This
protocol
involves
C−S
and
C−N
bond
formation
exhibits
good
functional
group
tolerance.
The
proceeded
well
at
room
temperature
provided
up
to
98%
yield
desired
products.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(16), P. 2565 - 2571
Published: April 26, 2024
Abstract
Visible-light
photocatalytic
reactions
between
enaminones
and
thioureas
leading
to
thiazole
products
have
been
achieved.
The
annulation
process
consists
of
tandem
C–S
C–N
bond
formation
by
running
under
air
atmosphere
at
ambient
temperature.
Broad
substrate
tolerance
the
sustainable
protocol
has
verified
practical
synthesis
divergent
thiazoles
with
both
monocyclic
fused
cyclic
structures.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 9078 - 9085
Published: June 3, 2024
The
α-C–H
trifluoromethylthiolation
of
N,N-disubstituted
enaminones
has
been
achieved
with
simple
and
cheap
CF3SO2Na
as
the
CF3S
source.
reactions
were
run
at
mild
temperature
(0
°C
to
rt)
using
POCl3
only
reducing
reagent.
work
represents
first
example
on
synthesis
α-trifluoromethylthio
via
direct
C–H
functionalization.
In
addition,
resulting
CF3S-functionalized
have
proven
useful
building
blocks
in
various
heteroaromatic
compounds
by
annulation
reactions.
