Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(10)
Published: Aug. 16, 2023
Abstract
To
assess
the
value
and
reactivity
of
new
photocatalysts
(PCs),
their
performance
should
be
evaluated
in
one
or
more
established
reactions
benchmarked
against
using
known
PCs.
Here,
we
our
recently
developed
PC,
pDTCz‐DPmS
,
a
C(sp)‐C(sp
3
)
cross‐coupling
reaction
that
had
been
documented
literature.
Previous
findings
indicated
this
could
not
proceed
absence
PC;
however,
under
conditions
was
case.
Without
moderate
product
yield
obtained,
while
increased
significantly
upon
addition
.
UV‐Vis
absorption
studies
Hantzsch
ester
(HE)
additive
acting
as
competitive
absorber
light
from
excitation
source,
quenching
confirmed
HE
quenched
by
radical
precursor,
N
‐(acyloxy)phthalimide.
Mechanistic
investigations
two
parallel
photosensitization
pathways
were
operation;
reductive
photocatalytic
pathway
(using
sacrificial
photoreductant
(employing
HE).
These
work
synergistically
to
enhance
target
product.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(8), P. 2746 - 2766
Published: Aug. 8, 2024
Photocatalysis
is
a
versatile
and
rapidly
developing
field
with
applications
spanning
artificial
photosynthesis,
photo-biocatalysis,
photoredox
catalysis
in
solution
or
supramolecular
structures,
utilization
of
abundant
metals
organocatalysts,
sustainable
synthesis,
plastic
degradation.
In
this
Perspective,
we
summarize
conclusions
from
an
interdisciplinary
workshop
young
principal
investigators
held
at
the
Lorentz
Center
Leiden
March
2023.
We
explore
how
diverse
fields
within
photocatalysis
can
benefit
one
another.
delve
into
intricate
interplay
between
these
subdisciplines,
by
highlighting
unique
challenges
opportunities
presented
each
multidisciplinary
approach
drive
innovation
lead
to
solutions
for
future.
Advanced
collaboration
knowledge
exchange
across
domains
further
enhance
potential
photocatalysis.
Artificial
photosynthesis
has
become
promising
technology
solar
fuel
generation,
instance,
via
water
splitting
CO
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 22, 2024
Abstract
Carbon
isotope
labelling
of
bioactive
molecules
is
essential
for
accessing
the
pharmacokinetic
and
pharmacodynamic
properties
new
drug
entities.
Aryl
carboxylic
acids
represent
an
important
class
structural
motifs
ubiquitous
in
pharmaceutically
active
are
ideal
targets
installation
a
radioactive
tag
employing
isotopically
labelled
CO
2
.
However,
direct
incorporation
via
reported
catalytic
reductive
carboxylation
(CRC)
aryl
electrophiles
relies
on
excess
,
which
incompatible
with
carbon-14
incorporation.
Furthermore,
application
some
CRC
reactions
late-stage
limited
because
low
tolerance
molecular
complexity
by
catalysts.
Herein,
we
report
development
practical
affordable
Pd-catalysed
electrocarboxylation
setup.
This
approach
enables
use
near-stoichiometric
14
generated
from
primary
source
Ba
3
facilitating
single-step
pharmaceuticals
representative
precursors.
The
proposed
isotope-labelling
protocol
holds
significant
promise
immediate
impact
programmes.
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
16(11)
Published: Jan. 15, 2024
Abstract
Visible‐light‐activated
organic
reactions
unlock
novel
avenues
for
complex
molecular
transformations,
impossible
under
standard
“thermal”
conditions,
which
makes
them
powerful
tools
in
the
arsenal
of
synthetic
chemistry.
However,
transition
metal‐based
or
photoredox
catalysts
are
often
used
to
ensure
productive
absorption
visible
light,
might
be
not
desirable
medicinal
chemistry
and
industry
due
toxicity,
low
sustainability,
high
cost
most
photocatalysts.
A
more
environmentally
economically
benign
approach
is
based
on
formation
transient
electron
donor‐acceptor
(EDA)
complexes
between
two
reagents
a
reagent
an
additive,
that
readily
absorb
acting
as
internal
photosensitizers.
Within
EDA
complex‐based
arylation
strategies,
chemical
transformations
mediated
by
noncovalent
interaction
molecules,
namely
electron‐poor
aryl
halides
their
equivalents
electron‐rich
nucleophilic
additives.
Moreover,
besides
stoichiometric
organocatalysis
can
achieved
certain
cases
through
regeneration
donor
molecules
course
reaction.
Photoexcitation
induces
single
transfer
(SET)
process
generate
radical
species
step.
This
Review
will
focus
state‐of‐the‐art
strategies
utilizing
halides,
aryldiazonium,
diaryliodonium,
arylsulfonium
arylphosphonium
salts
reactants,
published
mainly
last
five
years.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(37), P. 20344 - 20354
Published: July 25, 2023
Organic
molecules
that
can
be
connected
to
multiple
substrates
by
sequential
C-C
bond
formations
utilized
as
linchpins
in
multicomponent
processes.
While
they
are
useful
for
rapidly
increasing
molecular
complexity,
most
of
the
reported
linchpin
coupling
methods
rely
on
use
organometallic
species
strong
carbon
nucleophiles
form
bonds,
which
narrows
functional
group
compatibility.
Here,
we
describe
a
metal-free,
radical-mediated
approach
using
formyl-stabilized
phosphonium
ylide
multifunctional
under
visible-light
photoredox
conditions.
The
present
method
uses
ambiphilic
character
ylide,
serves
both
nucleophilic
and
an
electrophilic
carbon-centered
radical
source.
stepwise
controllable
generation
these
intermediates
allows
photocatalysis
involving
two
mechanistically
distinct
additions,
initiated
same
photocatalyst
one
pot
with
high
tolerance.
methodology
enables
bidirectional
assembly
electronically
differentiated
alkene
fragments
thus
offers
rapid
modular
access
1,4-dicarbonyl
compounds
versatile
synthetic
intermediates.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(16), P. 11967 - 11973
Published: July 26, 2024
Herein,
a
photoredox-neutral
strategy
for
carboxylation
of
acylated
alcohols
via
C(sp3)–O
bond
activation
and
cleavage
with
tetrabutylammonium
oxalate
(TBAO)
as
the
carbonyl
source
reductant
well
promoter
is
described.
Neither
pre-established
CO2
atmosphere
nor
external
electron
donors
are
required
TBAO
crucial
transformation.
Various
primary,
secondary,
tertiary
could
be
smoothly
converted
to
corresponding
aryl
acetic
acids,
which
core
structures
diverse
pharmaceutical
drugs.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(36), P. 14739 - 14745
Published: Jan. 1, 2024
The
strong
photoreducing
abilities
of
the
investigated
TADF
chromophores
is
result
photogeneration
solvated
electrons
in
a
consecutive
two-photon
induced
mechanism
(ConPies).
