Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
Abstract
N
‐oxyl
radicals
occupy
an
important
place
in
free‐radical
oxidative
CH‐functionalization
being
one
of
the
most
efficient
redox‐organocatalysts
for
hydrogen
atom
abstraction
(HAT).
Their
applications
include
aerobic
radical
chain
autoxidation,
with
formation
carbon‐carbon
and
carbon‐heteroatom
bonds.
The
persistent
nature
N‐
oxyl
combined
their
high
reactivity
HAT
results
unique
dual
chemistry:
same
can
both
propagate
reaction
(at
low
concentrations)
effectively
“terminate”
carbon‐centered
higher
concentrations).
latter
case
opens
a
new
synthetic
application
area
radicals,
which
they
act
as
abstracting
species
O‐reagents
cross‐coupling
thus
produced.
Apart
from
C−H
bond
cleavage,
reactive
have
been
extensively
used
recently
C=C
double
functionalization
via
addition
reactions.
In
this
review,
reactions
introduction
fragments
alkene
difunctionalizations
by
oxyls
are
covered
emphasis
on
relationship
between
conditions
selectivity.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(17), P. 6728 - 6732
Published: Jan. 1, 2023
An
electrochemical
three-component
cascade
reaction
of
aryl
acids,
nitriles,
and
alkylbenzenes
was
developed
for
the
synthesis
imides.
The
products
could
be
applied
to
synthesize
amides,
as
well
primary
or
tertiary
amines.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(6), P. 1205 - 1212
Published: Jan. 1, 2024
Hydroxyl
radical-induced
selective
N
-α
C(sp
3
)–H
bond
oxidation
of
amides
was
investigated
via
the
visible-light-induced
homolysis
(VLIH)
iron(
iii
)
complexes.
The Chemical Record,
Journal Year:
2023,
Volume and Issue:
24(3)
Published: Dec. 8, 2023
Herein,
we
provide
eco-friendly
and
safely
operated
electrocatalytic
methods
for
the
selective
oxidation
directly
or
with
water,
air,
light,
metal
catalyst
other
mediators
serving
as
only
oxygen
supply.
Heavy
metals,
stoichiometric
chemical
oxidants,
harsh
conditions
were
drawbacks
of
earlier
oxidative
cleavage
techniques.
It
has
recently
come
to
light
that
a
crucial
stage
in
deconstruction
plastic
waste
utilization
biomass
is
activation
inert
C(sp
Current Opinion in Green and Sustainable Chemistry,
Journal Year:
2024,
Volume and Issue:
46, P. 100896 - 100896
Published: Feb. 14, 2024
Organic
electrochemistry
has
recently
witnessed
a
renaissance
in
research
as
green
and
cost-efficient
method
for
activating
small
molecules.
Although
some
of
the
critical
challenges
batch
electrosynthesis
remain,
flow
can
overcome
several
issues
arising
from
electroorganic
systems,
such
mass
transfer,
ohmic
drop,
selectivity.
The
combination
technology
with
affords
practitioners
very
precise
control
over
reaction
conditions,
thereby
enhancing
reproducibility
electrochemical
processes.
use
gases
chemical
reactions
synthesis
value-added
fine
chemicals
is
great
significance.
This
review
summarizes
recent
advances
biphasic
(gas-liquid)
organic
synthesis.
We
summarise
examples
selective
hydrocarbon
oxidations
using
oxygen
gas
an
reactor.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(32)
Published: May 14, 2024
Abstract
We
report
an
electrochemically
promoted
decarboxylation
of
readily
available
carboxylic
acid
and
subsequent
Mumm
rearrangement
to
synthesize
the
corresponding
imides.
The
reaction
features
external
oxidant‐free,
transition
metal‐free
mild
conditions,
good
functional
group
tolerance,
affording
various
imides
in
moderate
yields.
Mechanistic
studies
reveal
that
selective
oxidation
aliphatic
acids
appears
be
key
step
this
transformation.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(12), P. 2851 - 2851
Published: June 15, 2024
With
the
growing
significance
of
green
chemistry
in
organic
synthesis,
electrochemical
oxidation
has
seen
rapid
development.
Compounds
undergo
oxidation–reduction
reactions
through
electron
transfer
at
electrode
surface.
This
article
proposes
use
methods
to
achieve
cleavage
benzyl
C–N
bond.
method
selectively
oxidatively
cleaves
bond
without
need
for
metal
catalysts
or
external
oxidants.
Additionally,
primary,
secondary,
and
tertiary
amines
exhibit
good
adaptability
under
these
conditions,
utilizing
water
as
sole
source
oxygen.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(50), P. 49825 - 49831
Published: Dec. 2, 2024
The
electrochemically
induced
reaction
between
alkenes,
bearing
an
allylic
hydrogen
atom,
and
N-hydroxyphthalimide
was
investigated.
Cross-dehydrogenative
C–O
coupling
with
phthalimide-N-oxyl
radical,
derived
from
N-hydroxyphthalimide,
occurs
instead
of
oxidation
the
site,
formation
a
carbonyl
group
or
functionalization
double
C═C
bond.
discovered
transformation
proceeds
in
undivided
electrochemical
cell
equipped
carbon
felt
anode
platinum
cathode.
Coupling
products
were
obtained
yields
up
to
79%.
developed
process
is
based
on
abstraction
atom
position
for
while
bond
remains
unreacted.
method
exploits
ability
radical
abstract
atoms
following
interception
intermediate
C-centered
radical.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(44)
Published: Oct. 14, 2024
Abstract
A
simple
base
mediated,
highly
regioselective
1,4‐hydroamidation
of
β
‐CF
3
‐1,3‐enynamides
with
secondary
amides
for
synthesis
tri‐substituted
γ
‐allenamides
compounds
was
developed.
N
‐alkyl
sulfonamides
are
generally
good
candidates
the
present
transformation.
could
be
employed
potential
value‐added
such
as
fluorinated
halogenated
pyrrole,
tetrahydroquinoline
and
2‐CF
‐putrescine
derivatives.
