Base‐Catalyzed [4+2] Annulation of Ynones and Acetates for the Synthesis of 2‐Pyrones DOI
Ting Chen,

Mao-Chun Ye,

Ting Huang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract An efficient, practical, and scalable Cs 2 CO 3 ‐catalyzed [4+2] annulation reaction between ynones acetates is presented, wherein serve as the four‐atom partners. This methodology facilitates synthesis of substituted 2‐pyrones with yields ranging from good to excellent. The ready availability starting materials, coupled simplicity protocol, renders this approach highly amenable preparation a diverse range 2‐pyrones. Furthermore, feasibility on gram scale its application in potent selective cyclooxygenase‐2 inhibitor underscore practical significance utility method.

Language: Английский

Synthesis of indolizines via Pd-catalyzed selective ring recasting of oxazolidines with deesterification of methyl acrylates DOI

Ya Pan,

Xianjun Xu,

Junwei Li

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2025, Volume and Issue: 46, P. 102059 - 102059

Published: June 5, 2025

Language: Английский

Citations

0
Seven-membered ring systems DOI

R. Alan Aitken

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 485 - 496

Published: Jan. 1, 2024

Citations

3
Ag(I)-Mediated Annulation of 2-(2-Enynyl)pyridines and Propargyl Amines to Access 1-(2H-Pyrrol-3-yl)indolizines DOI
Feng Li, Qing Yang, Mingyue Liu

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 89(1), P. 304 - 312

Published: Dec. 21, 2023

An effective Ag(I)-mediated annulation of 2-(2-enynyl)pyridines and propargyl amines was developed, unexpectedly affording a broad range functionalized 1-(2H-pyrrol-3-yl)indolizines in moderate to excellent yields. The developed method is characterized by operational simplicity, ready availability starting materials, high regioselectivity, substrate scope under mild reaction conditions. Ag(I)-promoted cyclization possibly results the formation spiroindolizine, ring-opening rearrangement which may give 1-(2H-pyrrol-3-yl)indolizine. Furthermore, gram-scale synthetic transformations are also studied.

Language: Английский

Citations

4
Silver(I)-Promoted [3 + 3]-Cycloaddition of 2-(2-Enynyl)quinolines with N′-(2-Alkynylbenzylidene)hydrazides DOI
Feng Li, Qing Yang,

He Li

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(16), P. 11567 - 11575

Published: Aug. 1, 2024

An effective and straightforward Ag(I)-mediated annulation of 2-(2-enynyl)quinolines N'-(2-alkynylbenzylidene)hydrazides was developed, forging various synthetically challenging 17bH-isoquinolino[2'',1'':1′,6']pyridazino[4′,5′:3,4]pyrrolo[1,2-a]quinolines, including different nitrogen-containing fused rings, in moderate to excellent yields. This one-pot cycloaddition strategy features exclusive regioselectivity, high atom economy, broad substrate scope under mild conditions. The practicality reliability this reaction demonstrated by a successful scale-up synthesis.

Language: Английский

Citations

0
Base‐Catalyzed [4+2] Annulation of Ynones and Acetates for the Synthesis of 2‐Pyrones DOI
Ting Chen,

Mao-Chun Ye,

Ting Huang

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract An efficient, practical, and scalable Cs 2 CO 3 ‐catalyzed [4+2] annulation reaction between ynones acetates is presented, wherein serve as the four‐atom partners. This methodology facilitates synthesis of substituted 2‐pyrones with yields ranging from good to excellent. The ready availability starting materials, coupled simplicity protocol, renders this approach highly amenable preparation a diverse range 2‐pyrones. Furthermore, feasibility on gram scale its application in potent selective cyclooxygenase‐2 inhibitor underscore practical significance utility method.

Language: Английский

Citations

0