Photochemical routes to artemisinin DOI

Marike Lancel,

Bryan Tambosco,

Zacharias Amara

et al.

Royal Society of Chemistry eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 301 - 330

Published: Dec. 20, 2023

Since its discovery in 1971, artemisinin has been and continues to be at the forefront of fight against malaria. The commercial importance this compound fuelled historical breakthrough innovations over past decades. Among them, synthetic biology photochemistry have two transformative technologies. focus book chapter is highlight tremendous developments which made field context. This summarizes early investigations on biosynthesis total synthesis involving as a key step, led foundation today’s large scale photochemical process developed operated by Sanofi 2013. However, market competition further investments developments, particular using continuous flow reactors more recently, development new recyclable bifunctional photocatalytic systems well routes become increasingly cost-efficient sustainable.

Language: Английский

Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop DOI Creative Commons
Sebastian B. Beil, Sylvestre Bonnet, Carla Casadevall

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(8), P. 2746 - 2766

Published: Aug. 8, 2024

Photocatalysis is a versatile and rapidly developing field with applications spanning artificial photosynthesis, photo-biocatalysis, photoredox catalysis in solution or supramolecular structures, utilization of abundant metals organocatalysts, sustainable synthesis, plastic degradation. In this Perspective, we summarize conclusions from an interdisciplinary workshop young principal investigators held at the Lorentz Center Leiden March 2023. We explore how diverse fields within photocatalysis can benefit one another. delve into intricate interplay between these subdisciplines, by highlighting unique challenges opportunities presented each multidisciplinary approach drive innovation lead to solutions for future. Advanced collaboration knowledge exchange across domains further enhance potential photocatalysis. Artificial photosynthesis has become promising technology solar fuel generation, instance, via water splitting CO

Language: Английский

Citations

19

Iron(III) Complexes with Luminescence Lifetimes of up to 100 ns to Enhance Upconversion and Photocatalysis DOI Creative Commons
Joël Wellauer, Björn Pfund,

Isabelle Becker

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Iron is the most abundant transition metal element and would be ideal replacement for noble metals in many applications that rely on luminescent long-lived electronically excited states. We show efficient reversible energy transfer between doublet states of iron complexes triplet organic ligands improves storage by up to 350-fold. As a result, luminescence lifetimes 100 ns are achieved, upconversion from red blue light becomes 68 times more yield benchmark photoredox reactions significantly improved. These advances make coordination compounds promising candidates lighting, solar conversion photocatalysis.

Language: Английский

Citations

2

Continuous Flow Approach for Benzylic Photo-oxidations Using Compressed Air DOI Creative Commons

Ruairí Bannon,

Gary Morrison,

Megan Smyth

et al.

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(8), P. 3307 - 3312

Published: July 24, 2024

A continuous flow approach for the aerobic photo-oxidation of benzylic substrates to ketone and aldehyde products is presented. The resulting process exploits UV-A LEDs (375 nm) in combination with a Corning AFR reactor that ensures effective gas-liquid mixing leads short residence times 1 min. variety are converted their corresponding carbonyl products, scalability demonstrated produce multigram quantities within few hours. Overall, this offers several improvements over alternative oxidation methods due combined use air as an oxidant SAS (sodium anthraquinone-2 sulfonate) water-soluble photocatalyst. greener safer conditions together intensification principles renders attractive further industrial applications.

Language: Английский

Citations

14

Photocatalyst‐ and Transition‐Metal‐Free Light‐Induced Formation of Carbon‐Chalcogen Bonds DOI
Rosalin Bhanja, Shyamal Kanti Bera, Prasenjit Mal

et al.

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 366(2), P. 168 - 182

Published: Dec. 16, 2023

Abstract Photoinduced chemical transformations have become a promising aspect of organic synthesis. This review focuses on the recent advancements in harnessing photoinduced processes for formation carbon‐chalcogen (C−O, C−S, C−Se, and C−Te) bonds under catalyst‐free conditions. These pathways typically involve either radical mechanism or creation electron‐donor‐acceptor (EDA) complexes. The explores intricacies underlying mechanisms, discusses limitations, evaluates applicability various methodologies this field. Notably, photocatalyst transition metal‐free photochemical reactions offer effective alternatives to enhance sustainability research area.

Language: Английский

Citations

16

Thermosensitive four-arm star-shaped copolymers with phthalocyanine as core and porphyrin copolymer as arms was used as visible light photocatalyst DOI

Shan Wu,

Jian‐Wen Shi, Qian Duan

et al.

Journal of Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 116009 - 116009

Published: Feb. 1, 2025

Language: Английский

Citations

0

The Photochemistry of Quinones and Combustion-derived Particles in Forming Hydroxyl Radicals and Singlet Oxygen in the Atmosphere DOI
Desiree J. Sarmiento, Brian J. Majestic

Atmospheric Environment, Journal Year: 2025, Volume and Issue: unknown, P. 121189 - 121189

Published: March 1, 2025

Language: Английский

Citations

0

Sustainable Photooxidation using a Subpart-per-million Heavy-Metal-Free Red-Light Photocatalyst DOI
Maxime Lancel,

Tamara Golisano,

Cyrille Monnereau

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2023, Volume and Issue: 11(43), P. 15674 - 15684

Published: Oct. 15, 2023

Photochemical activation using red or near-infrared light has recently emerged as a potential remedy for solving fundamental issues in photochemistry such selectivity and scale up. However, this is particularly challenging the case of photooxidation chemistry due to low resistance photobleaching poor solubility photocatalysts absorbing region electromagnetic spectrum. In study, we report use commercially available Si-phthalocyanines robust environmentally friendly class soluble photosensitizers activated under light. Interestingly, while exhibit lower singlet oxygen generation (ϕΔ) quantum yields compared classical photosensitizers, their high stability enables us achieve comparable efficiencies at ultralow catalytic loadings (ppb range). This unique feature provides performances range photooxidative processes substrate concentrations ultimately leading safe efficient solvent-free continuous flow applied multigram-scale synthesis.

Language: Английский

Citations

6

Scalable and green juglone synthesis via heterogeneous photocatalysis in a photomicroreactor DOI
Mohsin Pasha, Y. Andrew Wang,

You Ma

et al.

Catalysis Science & Technology, Journal Year: 2024, Volume and Issue: 14(19), P. 5755 - 5763

Published: Jan. 1, 2024

A green and scalable heterogeneous photocatalysis platform is efficiently established for multigram juglone production using photomicroreactors, which are at the forefront of sustainable flow chemistry.

Language: Английский

Citations

1

Multi-defense Pathways against Electrophiles through Adduct Formation by Low Molecular Weight Substances with Sulfur Atoms DOI Creative Commons
Yoshito Kumagai,

Yumi Abiko,

Masahiro Akiyama

et al.

Toxicological Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

There is a variety of electrophiles in the environment. In addition, there are precursor chemicals that undergo metabolic activation by enzymes and conversion to body. Although covalently bind protein nucleophiles, they also form adducts associated with adaptive or toxic responses. Low molecular weight compounds containing sulfur capable blocking such adduct formation capturing electrophiles. this review, we present out findings on capture inactivation 1) intracellular glutathione, 2) reactive species 3) extracellular cysteine (formed during production adducts). These actions not only substantially suppress electrophilic activity but regulate formation.

Language: Английский

Citations

0

Batch to Continuous Flow Visible‐Light Photooxidations Using Alumina Supported Hydroxyanthraquinones DOI Creative Commons

Yahya Al Ayi,

Augustin Pirenam Atakpa,

Celine Arab

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(43)

Published: Nov. 9, 2024

Abstract The discovery of new environmentally friendly recyclable photosensitizers is key to develop future applications in photooxidation chemistry. We report here the evaluation a set differently substituted biobased hydroxyanthraquinones context visible light mediated singlet oxygen ( 1 O 2 ) photochemistry. This class compounds efficiently immobilized on alumina supports, which offers simple way removing them from reaction mixture downstream. An integrated process using flow reactor with fixed catalytic bed also evaluated and its performance compared homogeneous conditions.

Language: Английский

Citations

0