Linear and Angular Heteroannulated Pyridines Tethered 6-Hydroxy-4,7-Dimethoxybenzofuran: Synthesis and Antimicrobial Activity

Molecules, Journal Year: 2024, Volume and Issue: 29(18), P. 4496 - 4496

Published: Sept. 22, 2024

2-Chloropyridine-3-carbonitrile derivative 1 was utilized as a key precursor to build series of linear and angular annulated pyridines linked 6-hydroxy-4,7-dimethoxybenzofuran moiety. Reaction substrate with various hydrazines afforded pyrazolo[3,4-b]pyridines. Treatment 1,3-N,N-binucleophiles including 3-amino-1,2,4-triazole, 5-amino-1H-tetrazole, 3-amino-6-methyl-1,2,4-triazin-5(4H)-one 2-aminobenzimidazole produced the novel pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrimidine, pyrido[3,2-e][1,2,4]tetrazolo[1,5-a]pyrimidine, pyrido[3′,2′:5,6] pyrimido[2,1-c][1,2,4]triazine benzo[4,5]imidazo[1,2-a]pyrido[3,2-e]pyrimidine, respectively. 1,3-C,N-binucleophiles cyanoacetamides 1H-benzimidazol-2-ylacetonitrile furnished 1,8-naphthyridines benzoimidazonaphthyridine. Moreover, reacting 5-aminopyrazoles gave pyrazolo[3,4-b][1,8]naphthyridines. Finally, reaction compound 6-aminouracils cyclic enamines yielded pyrimido[4,5-b][1,8]naphthyridines. Some synthesized products showed noteworthy antimicrobial efficiency against all types microbial strains. Structures compounds were established using analytical spectroscopic tools.

Language: Английский

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Facile and diverse synthesis of indolyl substituted 4,5,6,7-tetrahydro-4H-indol-4-ones and 1,6-dihydropyrrolo[2,3-c]pyrazol via multi-component reactions

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: unknown, P. 155444 - 155444

Published: Dec. 1, 2024

Language: Английский

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Synthesis of nicotinimidamides via a tandem CuAAC/ring-cleavage /cyclization/oxidation four-component reaction and their cytotoxicity

RSC Advances, Journal Year: 2024, Volume and Issue: 14(35), P. 25844 - 25851

Published: Jan. 1, 2024

Nicotinamide and its derivatives, recognized as crucial drug intermediates, have been a focal point of extensive chemical modifications rigorous pharmacological studies. Herein, series novel nicotinamide nicotinimidamides, were synthesized

Language: Английский

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Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(36)

Published: Sept. 1, 2024

Abstract Over the last three decades, owing to labour cost, time and especially environmental issues, one‐pot synthesis of heterocyclic compounds involving tandem or multicomponent (sequential consecutive) reactions has gained particular attention worldwide. Most marketed drug molecules hold one more rings. Due some side effects several drugs along with gradual emergence antimicrobial resistance, necessity for developing new continues; special should be paid in this respect towards employing their syntheses. Pyrazolopyridines are fused heterocycles holding pyridine pyrazole possess a wide variety biological pharmaceutical properties. Several existing also bear pyrazolopyridine scaffolds. The present perspective is an endeavour encompass green syntheses different isomeric systems, most these published during past five years few cases.

Language: Английский

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Five-membered ring systems: With more than 1 N atom

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 211 - 257

Published: Jan. 1, 2024

Language: Английский

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