Epigrammatic Review on Heterocyclic Moiety Pyrazole: Applications and Synthesis Routes

Mini-Reviews in Organic Chemistry, Journal Year: 2023, Volume and Issue: 21(6), P. 684 - 702

Published: Aug. 23, 2023

Abstract: Heterocyclic compounds are amongst the most promising and versatile classes of biologically important molecules. One heterocycle molecules is pyrazole with a five-membered heterocyclic ring two neighboring nitrogen. Pyrazole its derivatives have shown broad range biological applications like antibacterial, antifungal, antiviral, anti-inflammatory, anti-cancerous, herbicidal activities. The study synthetic routes suggests three ways: cyclo-condensation hydrazine on 1,3 difunctional systems, dipolar cycloadditions, multicomponent reactions. synthesis pyrazoles involves usage conventional catalyst more progressive efficient nanoparticles as catalysts. use nanocatalysts grabbing attention researchers owing to their efficacy reproducibility, low cost, reusability, ease production, etc. current review an epigrammatic importance moiety, recent advances in aforementioned synthesize derivatives, brief nanocatalysts.

Language: Английский

Concise approach for the synthesis of Voxelotor for sickle cell disease

Tetrahedron, Journal Year: 2023, Volume and Issue: 150, P. 133768 - 133768

Published: Dec. 3, 2023

Language: Английский

Cu/Pd-Catalyzed Domino Carbonylative Synthesis of Polycyclic Carbonyl-Containing Quinolin-2(1H)-one Scaffolds from α-Bromocarbonyls

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

A novel Cu/Pd-catalyzed domino radical cyclization and C-H carbonylation of α-bromocarbonyls has been developed, which enables the rapid incorporation CO unit into polycyclic quinolin-2(1

Language: Английский