Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Abstract
Oxetanes
are
valuable
motifs
in
medicinal
chemistry
applications,
with
demonstrated
potential
to
serve
as
bioisosteres
for
an
array
of
functional
groups.
Through
the
visible‐light‐mediated
photoredox
hydrodecarboxylation
2‐aryl
oxetane
2‐carboxylic
acids
this
work
enables
access
products
a
[2+2]‐photocycloaddition
between
alkenes
and
aryl
aldehydes
without
challenges
associated
traditional
UV‐light‐mediated
Paternò‐Büchi
reaction.
Investigation
into
mechanism
reveals
substrate‐dependent
modes
initiation
under
conditions
reported
herein.
Divergence
diastereomeric
outcome
is
observed,
mechanistic
probes
elucidating
key
hydrogen‐bonding
steric
interactions.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(22), P. 2773 - 2778
Published: July 16, 2024
Comprehensive
Summary
A
regiodivergent
synthesis
of
azetidines,
5,6‐dihydro‐1,3‐oxazines
and
2,3‐dihydro‐1,4‐oxazines
has
been
achieved
through
palladium‐catalyzed
tandem
allylic
substitution
reaction.
This
protocol
provides
a
variety
heterocycles
in
satisfactory
yields
with
good
to
excellent
regioselectivities
under
mild
reaction
conditions.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Abstract
Oxetanes
are
valuable
motifs
in
medicinal
chemistry
applications,
with
demonstrated
potential
to
serve
as
bioisosteres
for
an
array
of
functional
groups.
Through
the
visible‐light‐mediated
photoredox
hydrodecarboxylation
2‐aryl
oxetane
2‐carboxylic
acids
this
work
enables
access
products
a
[2+2]‐photocycloaddition
between
alkenes
and
aryl
aldehydes
without
challenges
associated
traditional
UV‐light‐mediated
Paternò‐Büchi
reaction.
Investigation
into
mechanism
reveals
substrate‐dependent
modes
initiation
under
conditions
reported
herein.
Divergence
diastereomeric
outcome
is
observed,
mechanistic
probes
elucidating
key
hydrogen‐bonding
steric
interactions.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 13, 2024
Abstract
Oxetanes
are
valuable
motifs
in
medicinal
chemistry
applications,
with
demonstrated
potential
to
serve
as
bioisosteres
for
an
array
of
functional
groups.
Through
the
visible‐light‐mediated
photoredox
hydrodecarboxylation
2‐aryl
oxetane
2‐carboxylic
acids
this
work
enables
access
products
a
[2+2]‐photocycloaddition
between
alkenes
and
aryl
aldehydes
without
challenges
associated
traditional
UV‐light‐mediated
Paternò‐Büchi
reaction.
Investigation
into
mechanism
reveals
substrate‐dependent
modes
initiation
under
conditions
reported
herein.
Divergence
diastereomeric
outcome
is
observed,
mechanistic
probes
elucidating
key
hydrogen‐bonding
steric
interactions.
