Five-membered ring systems: With more than 1 N atom DOI
Larry Yet

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 211 - 257

Published: Jan. 1, 2024

Language: Английский

Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications DOI
Shuai Liu, Jun Zhou, Lu Yu

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Fluorine and nitrogen form a successful partnership in organic synthesis, medicinal chemistry, material sciences. Although fluorine-nitrogen chemistry has long rich history, this field received increasing interest made remarkable progress over the past two decades, driven by recent advancements transition metal organocatalysis photochemistry. This review, emphasizing contributions from 2015 to 2023, aims update state of art synthesis applications nitrogen-based organofluorine functional molecules chemistry. In dedicated sections, we first focus on fluorine-containing reagents organized according type groups attached nitrogen, including N-F, N-RF, N-SRF, N-ORF. review also covers nitrogen-linked building blocks, catalysts, pharmaceuticals, agrochemicals, underlining these components' broad applicability growing importance modern

Language: Английский

Citations

0
Synthesis of Fully Substituted Difluoromethylpyrazoles by Cyclization of Difluoroacetohydrazonoyl Bromides with 2-Acylacetonitriles or Malononitrile DOI
Siwei Wang, Jianzhong Zhang,

Zhoubin Deng

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10591 - 10602

Published: July 12, 2024

A concise and efficient method for the construction of fully substituted difluoromethylpyrazoles is achieved by a cyclization reaction between difluoroacetohydrazonoyl bromides 2-acylacetonitrile or malononitrile. The features advantages such as mild conditions, broad substrate scope, good product yields, high regioselectivity.

Language: Английский

Citations

3
Transition‐Metal‐Catalyzed Reactions Involving Trifluoro Diazo Compounds and Their Surrogates DOI
Yeming Wang, Chaoqun Zhang,

Shizhe Li

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(27)

Published: May 22, 2024

Abstract Fluorinated organic compounds represent an important and growing family of active ingredients in various fields, including material science, pharmaceutical chemistry biological science. Developing efficient synthetic methods toward fluorinated have attracted much attention. In recent years, transition‐metal catalyzed reaction trifluoro diazo were a powerful convenient approach to afford trifluoromethyl‐ difluoromethyl‐substituted value. this review, the progress on transition‐metal‐catalyzed reactions involving their surrogates via trifluoromethylated carbene complex is described sequence 2,2,2‐trifluorodiazoethane as precursor, ethyl 3‐trifluoro‐2‐diazo‐propionate trifluoroethylamine hydrochloride or amines CF 3 CHN 2 surrogate well aldehydes/ketones N‐sulfonylhydrazones surrogate.

Language: Английский

Citations

3
Iodobenzene-Catalyzed Synthesis of Fully Functionalized NH-Pyrazoles and Isoxazoles from α,β-Unsaturated Hydrazones and Oximes via 1,2-Aryl Shift DOI
Vikram Singh, Deepak Kumar,

Bal Krishna Mishra

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 26(1), P. 385 - 389

Published: Dec. 27, 2023

An iodine(III)-catalyzed general method for the synthesis of fully functionalized NH-pyrazoles and isoxazoles from α,β-unsaturated hydrazones oximes, respectively, via cyclization/1,2-aryl shift/aromatization/detosylation, has been developed. The reaction progresses through an anti-Baldwin 5-endo-trig cyclization. It gives direct access to advanced intermediate preparation valdecoxib parecoxib, drugs used COX-inhibition. In addition, a N-alkynylation pyrazoles also developed in presence TIPS-EBX.

Language: Английский

Citations

7
Reagent- and solvent-controlled product divergence in the reaction of trifluorodiazoethane with arylidene-1,3-indanediones DOI

Mumtaz Ahmad,

Lubina Fatma,

Ruchir Kant

et al.

Journal of Fluorine Chemistry, Journal Year: 2024, Volume and Issue: 274, P. 110256 - 110256

Published: Feb. 1, 2024

Language: Английский

Citations

1
Recent Highlights in the Synthesis and Biological Significance of Pyrazole Derivatives DOI Creative Commons
Ziad Moussa, Mani Ramanathan,

Shaikha Mohammad Alharmoozi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38894 - e38894

Published: Oct. 1, 2024

Language: Английский

Citations

1
Zinc‐Catalysed [3+2] Cycloaddition of Enaminone with Tosylhydrazide to Synthesise 1H‐pyrazole via C–N and S–N Bond Cleavage DOI
Sanjukta Roy, Rana Chatterjee, Rambabu Dandela

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract A novel and practical zinc‐catalysed synthesis of 1 H ‐pyrazole has been developed. The one‐pot protocol enables the cycloaddition enaminone tosylhydrazide via C−N S−N bond breaking process, leading to diverse mono‐substituted pyrazole derivatives in high yields. Moreover, easily accessible materials, broad substrate scope with excellent functional group tolerance, ease isolation open‐air conditions are key features present method.

Language: Английский

Citations

1
Five-membered ring systems: With more than 1 N atom DOI
Larry Yet

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 211 - 257

Published: Jan. 1, 2024

Language: Английский

Citations

0