Spiro-Heterocycles: Recent Advances in Biological Applications and Synthetic Strategies

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134468 - 134468

Published: Jan. 1, 2025

Language: Английский

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An overview of the synthesis of biheterocyclic compounds featuring four-membered rings containing nitrogen, oxygen, or sulfur

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134679 - 134679

Published: April 1, 2025

Language: Английский

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DBU catalyzed (3 + 3) annulation of β′ and δ-acetoxy allenoates with benzo-oxathiin-dioxide and phenylthiazolone: Synthesis of pyrano-oxathiines and pyrano-thiazoles

Journal of Chemical Sciences, Journal Year: 2024, Volume and Issue: 136(4)

Published: Oct. 4, 2024

Language: Английский

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Diastereoselective Synthesis of Fused Tricyclic Pyridopyrimidines via Tandem Cyclization of Allenoates and Cyclic Amidines

Organic Letters, Journal Year: 2023, Volume and Issue: 25(42), P. 7711 - 7715

Published: Oct. 16, 2023

The tandem cyclization of easily accessible allenoates and cyclic amidines for the synthesis functionalized tricyclic pyridopyrimidines is reported herein. annulation featured a broad substrate scope with good functional group tolerance under very mild conditions (35 examples, 32–85% yields). were obtained in short reaction time (1 min), at room temperature, neat conditions, which offers an alternative way to sustainable pyridopyrimidines. scalability developed protocol further demonstrated by gram-scale synthesis.

Language: Английский

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TBD-Mediated Diastereoselective Access to Functionalized 3-Alkenyl-2-oxindoles via the Tandem Reaction of Isatins and Allenoates

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(19), P. 14021 - 14027

Published: Sept. 20, 2024

The 1,5,7-triazabicyclo[4.4.0]dec-5-ene-mediated tandem reaction of easily accessible isatins and allenoates to functionalized 3-alkenyl-2-oxindoles is disclosed. allows the synthesis a wide range in good yields with excellent functional group tolerance under mild conditions (32 examples, up 84% yields). current strategy will provide novel path for sustainable 3-alkenyl-2-oxindole derivatives. We have also demonstrated significance as key starting materials (KSMs) via their synthetic utility producing oxindole-appended pyrazole, oxazole, coumarin hybrids medicinal relevance.

Language: Английский

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Phosphine vs DBU-Catalyzed Annulation Reactions of β′-Acetoxy Allenoates with Acyl-Tethered Benzothiazole Bisnucleophiles: (4 + 3) or (4 + 1) vs (3 + 3) Annulation

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10816 - 10830

Published: July 15, 2024

Dearomative annulation reaction of acyl-tethered benzothiazole bisnucleophiles with β'-acetoxy allenoates by switching the Lewis base is developed. The DBU-catalyzed gives benzothiazole-fused 1,4-dihydropyridine carboxylates (3 + 3) chemoselectively. By contrast, PR

Language: Английский

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Four-membered ring systems

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 59 - 87

Published: Jan. 1, 2024

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DABCO-catalyzed [3 + 4] annulations of Schiff bases with α-substituted allenes: Construction of functionalized benzazepine derivatives

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110646 - 110646

Published: Nov. 1, 2024

Language: Английский

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Access to Spiro-oxetane Oxindoles via DBU-Catalyzed Activation of Allenoates

Synfacts, Journal Year: 2023, Volume and Issue: 19(10), P. 0972 - 0972

Published: Sept. 14, 2023

Key words oxetanes - oxindoles spiro-annulation allenoates

Language: Английский

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