Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1299, P. 137217 - 137217
Published: Dec. 1, 2023
Language: Английский
Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1299, P. 137217 - 137217
Published: Dec. 1, 2023
Language: Английский
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(2), P. 1310 - 1314
Published: Jan. 3, 2024
We report an efficient route for the synthesis of highly substituted 1-aminonaphthalenes from benzaldehydes. The method employs a stereoselective Still–Gennari modification Horner–Wadsworth–Emmons olefination to afford (E)-benzylidenesuccinonitrile precursors, which undergo Bronsted acid mediated benzannulation 1-aminonaphthalene derivatives in 35–95% yield. abundance commercially available benzaldehydes, coupled with simplicity our method, enables many previously unexplored naphthalene substitution patterns become readily accessible.
Language: Английский
Citations
0Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1299, P. 137217 - 137217
Published: Dec. 1, 2023
Language: Английский
Citations
0