Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 497 - 517
Published: Jan. 1, 2024
Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 1839 - 1879
Published: Aug. 1, 2024
The Groebke–Blackburn–Bienaymé (GBB) three-component reaction, discovered in 1998, is a very efficient strategy to assemble imidazo[1,2- ]-heterocycles starting from amidines, aldehydes and isocyanides. This review aims exhaustively describe innovative aspects of this reaction achieved during the last five years, classifies them into categories: synthetic methods, building blocks, scaffolds, biological activities physical properties.
Language: Английский
Citations
5
The Chemical Record, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
The exploration of macrocycles began in the 20th century, coinciding with progressive advancement synthetic chemistry methodologies. From numerous strategies, Ugi reaction stands out as an efficacious four-component (4-CR). is particularly distinguished by its robust functional group tolerance, enabling creation that are both diverse and complex a singular step. This review collates contemporary examples macrocycles, all which have been crafted using to construct these macrocyclic frameworks. employment various bifunctional reagents (with same or different groups), has introduced plethora cyclization tactics, resulting synthesis multitude cage molecules. In order offer invaluable insights into construction use distinct colors for reactants made entire process transparently visible, thereby enhancing readers' understanding sparking their interest.
Language: Английский
Citations
0
Chemical Communications, Journal Year: 2023, Volume and Issue: 59(97), P. 14411 - 14414
Published: Jan. 1, 2023
Utilizing CO2 as a one-carbon building block in the preparation of high-value chemical entities is cornerstone modern organic synthesis. Herein, we exemplify this strategy through mild, one-pot methodology that gives rapid access to N-heteroaryl substituted 6-, 8- and 9-membered carbamates via fixation.
Language: Английский
Citations
7
Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 1604 - 1613
Published: July 16, 2024
Parallel Groebke-Blackburn-Bienaymé reaction was evaluated as a source of multimillion chemically accessible chemical space. Two most popular classical protocols involving the use Sc(OTf)
Language: Английский
Citations
1
Methods, Journal Year: 2023, Volume and Issue: 220, P. 142 - 157
Published: Nov. 6, 2023
Language: Английский
Citations
3
Synlett, Journal Year: 2024, Volume and Issue: 35(15), P. 1828 - 1832
Published: Jan. 5, 2024
Abstract By exploiting the chemistry of bifunctional isocyanides, straightforward, rapid, and scalable Ugi-tetrazole-based multicomponent reaction heteroannulations were developed. Our synthetic approach provides a series diverse fused tetrazolo piperazinones 1,4-diazepanones in just one step.
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(8), P. 5375 - 5382
Published: Feb. 14, 2024
Octafluorocyclopentene (OFCP) has found utility as a polyelectrophile in substitution cascades that form complex macrocyclic compounds. The Harran group synthesis of polypeptides depends on OFCP linker, combining with four different nucleophilic units polypeptide. We report computational investigation the origins reactivity and rationale for controlled mono-, di-, tri-, tetrasubstitution fluoride ions by heteroatomic nucleophiles. roles inductive, negative hyperconjugative, resonance electron-donation substituents are explored reaction OFCP, less-fluorinated analogues, common electrophilic alkenes several
Language: Английский
Citations
0
European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: July 31, 2024
Abstract Cyclic N ‐sulfonyl ketimines constitute an accessible class of lead‐like heterocycles with a vast application in both synthetic organic and medicinal chemistry. In this context, we harness the capabilities these four different isocyanide‐based multicomponent reactions. Our goal was to create libraries compounds functional groups vectors that are compatible for structural elaboration optimization their physical properties. We synthesized 15 unprecedented high diversity complexity, whereas have obtained single crystal structures each scaffold, unraveling geometrical features potential employment drug discovery.
Language: Английский
Citations
0
Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 497 - 517
Published: Jan. 1, 2024
Citations
0