Cobalt(II)-Catalyzed Selective C2–H Heck Reaction of Native (N–H) Indoles Enabled by Salicylaldehyde Ligand

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Direct functionalization of native (N–H) indoles via C–H activation remains a challenge. Herein, we report salicylaldehyde-promoted cobalt-catalyzed selective C2–H Heck reaction with both active and unactivated olefins in the presence free N–H bonds. A series structurally diverse C2-alkenylated including natural product drug derivatives were prepared directly effectively without additional preprotection deprotection procedures.

Language: Английский

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Solvent-controlled switchable multicomponent tandem oxidative triple functionalization of indolines

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(7), P. 1933 - 1940

Published: Jan. 1, 2024

A new one-pot method for solvent-controlled switchable tandem oxidative triple functionalization of indolines has been developed via successive regioselective chalcogenation, oxidation, amination and halogenation.

Language: Английский

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Site Specific C3‐Alkenylation of Indoles Mediated by in situ C‐H Iodination

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract The C3‐alkenylation of indoles have been developed by means a novel in situ iodination tactic which is capable mediating the Heck coupling with alkenes. method features specific site‐selectivity oriented C−I bond, high‐step efficiency without pre‐functionalization for C‐halogen bond construction, as well highly general tolerance to different terminal alkenes, including unactivated acrylates, acrylic acid, vinyl sulfone functionalized natural products.

Language: Английский

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Recent advances in constructing efficient materials for electrocatalytic oxidation of propylene

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1323, P. 140778 - 140778

Published: Nov. 16, 2024

Language: Английский

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Synergistic Palladium/Silver/Ligand Catalysis for C−H Alkenylation of 2,1,3‐Benzofused Heterodiazoles

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract The combination of palladium and silver complexes has emerged as a bimetallic catalytic system in C−H activation, frequently outperforming palladium‐only systems. Beyond the conventional roles (I) salts serving oxidants, halide scavengers, Lewis acids, Pd−Ag synergism been shown to facilitate cleavage. In this study, we explore incorporation pyrazolopyridone (PzPyOH) ligand into system, which together promote both cleavage migratory insertion processes. This synergistic approach enables dehydrogenative alkenylations at C4 position 2,1,3‐benzothiadiazole, 2,1,3‐benzoxadiazole, 2,1,3‐benzotriazole with alkenes. These results demonstrate potential combining novel ligands heterobimetallic systems other elementary steps beyond cleavage, suggesting their broader applicability functionalization.

Language: Английский

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Salicylaldehyde-Enabled Co(II)-Catalyzed Oxidative C–H Alkenylation of Indoles with Olefins

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 90(1), P. 35 - 43

Published: Dec. 27, 2024

A ligand-promoted oxidative dehydrogenation C-H alkenylation of indoles and olefins was achieved using commercial low-cost Co(NO

Language: Английский

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