Journal for Research in Applied Sciences and Biotechnology,
Journal Year:
2024,
Volume and Issue:
3(4), P. 54 - 68
Published: Aug. 25, 2024
Current
advances
in
knowledge
about
peptides
as
drugs
are
of
great
significance;
They
have
planning
potentialities
different
sections
medicinal
practice.
This
review
will
summarize
the
progress
synthesis
and
biological
activities
peptide-based
drug,
along
with
some
uses.
We
start
historical
aspect
key
points
development
corresponding
field.
In
general,
part
describes
approaches
synthesis,
design
strategies,
screening
methods,
optimization
for
stability
bioavailability.
then
describe
action
such
mechanisms
respect
to
receptors,
enzymes,
that
can
penetrate
cells.
It
has
also
expanded
assessment
description
peptide
treatment
cancer,
cardiovascular
diseases,
metabolic
neurological
infectious
immunotherapy.
cover
both
problems
formation
like
stability,
delivery,
regulatory
issues
opportunities
nanotechnology,
bioprinting,
CRISPR.
Last,
we
discuss
outlook
therapeutics
features,
which
promising
new
trends
perspectives
application.
The
present
is
intended
give
an
up-to-date
easy
grasp
information
regarding
status
peptide-associated
medicines
contemporary
pharmacology.
Journal of Peptide Science,
Journal Year:
2025,
Volume and Issue:
31(5)
Published: April 10, 2025
ABSTRACT
This
perspective
essay
will
briefly
recount
fundamental
physicochemical
properties
of
the
peptide‐resin
that
have
led
to
almost
universal
use
stepwise
solid
phase
peptide
synthesis
(SPPS)
for
chemical
peptides.
The
discusses
multiple
aspects
must
be
addressed
if
we
are
develop
truly
green
synthesis.
An
optimal
SPPS
approach
retains
advantages
inherent
polymer‐supported
synthesis,
combined
with
convergent
based
on
modern
ligation
methods
condensation
unprotected
segments,
described
as
a
path
peptides
and
their
efficient
manufacture.
Only
most
pertinent
primary
literature
is
cited.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(17), P. 8521 - 8545
Published: Jan. 1, 2024
Methods
enabling
the
dechalcogenation
of
thiols
or
selenols
have
been
investigated
and
developed
for
a
long
time
in
fields
research
as
diverse
study
prebiotic
chemistry,
engineering
fuel
processing
techniques,
biomolecule
structures
function
chemical
synthesis
biomolecules.
The
thiol
selenol
amino
acids
is
nowadays
particularly
flourishing
area
being
pillar
modern
protein
synthesis,
when
used
combination
with
selenol-based
chemoselective
peptide
ligation
chemistries.
This
review
offers
comprehensive
scholarly
overview
field,
emphasizing
emerging
trends
providing
detailed
critical
mechanistic
discussion
methods
so
far.
Taking
advantage
recently
published
reports,
it
also
clarifies
some
unexpected
desulfurization
reactions
that
were
observed
past
which
no
explanation
was
provided
at
time.
Additionally,
includes
on
principal
within
framework
newly
introduced
green
chemistry
metrics
toolkits,
well-rounded
exploration
subject.
The
development
of
industrial
chromatography
is
typically
constrained
by
timelines
and
available
material.
For
the
design
continuous
multicolumn
processes
like
countercurrent
solvent
gradient
purification
(MCSGP),
required
material
consumption
during
(≈10
to
20
g)
a
major
issue.
In
this
work
we
present
method
based
on
mechanistic
modeling
MCSGP
operation
in
time-efficient
manner
such
as
result
process
that
easy
transfer,
fits
within
specific
facility.
Starting
from
viable
model,
workflow
consists
three
steps:
(i)
single
column
simulations
are
carried
out
identify
batch
runs
sufficient
quality,
assess
recycle
parameters
expected
fast
convergence
cyclic
steady
state
(CSS),
(ii)
all
suitable
transferred
following
common
pragmatic
approach
twin
simulated
until
state;
(iii)
facility
fit
investigated
scaling
up
adapting
equipment
for
commercial
production.
We
report
results
applying
context
an
case
study,
where
was
designed
synthetic
peptide.
highlight
how
methodology
allows
operating
conditions
meet
target
purity
robust
manner,
which
CSS
reached
few
cycles
only.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(31), P. 6787 - 6791
Published: July 29, 2024
The
widely
used
Fmoc/t-Bu
solid-phase
peptide
synthesis
(SPPS)
is
hampered
by
relying
on
corrosive,
per/polyfluoroalkyl
substance
(PFAS)
classified
trifluoroacetic
acid
(TFA)
as
a
universal
protecting
group
(PG)
removal/resin
cleavage
reagent.
We
report
that
suitable
combinations
of
Brønsted
acids
(BAs)
and
Lewis
(LAs)
such
HCl/FeCl3
AcOH/FeCl3
constitute
viable
alternatives
for
TFA
PFAS-free
agents.
Using
water
miscible
dimethyl
carbonate
(DMC)
acetonitrile
(MeCN)
solvents
enabled
diluting
mixtures
with
aqueous
solutions,
allowing
direct
use
in
purification
which
removal
>99.99%
iron
from
an
induced
was
demonstrated.
