Incredible Indolinedione Derivatives Nucleus in the Development of Anti‐Diabetic Drugs: Exploring the Mechanistic Studies, Design, and Structure‐Activity Relationship DOI

Aanchal Khanna,

Jyoti Jyoti, Nitish Kumar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract Diabetes mellitus, a prevalent metabolic disorder, necessitates continuous exploration for innovative therapeutic agents. Indolinedione has garnered attention its potential as an antidiabetic scaffold structurally diverse nucleus. The search novel and effective agents led to the of natural compounds synthetic derivatives. review commences with in‐depth biochemical underpinnings diabetes emphasizing rational design strategies employed modifying indolinedione nucleus, encompassing various methodologies aimed at enhancing pharmacological properties docking studies. multifaceted derivatives offer fertile ground further in preclinical clinical As research this field progresses, may emerge valuable addition arsenal therapeutics, providing new avenues management mellitus.

Language: Английский

Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives DOI

Yi-Xin Dong,

Lixin Gao, Qing Cao

et al.

The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: 128(25), P. 6123 - 6133

Published: June 14, 2024

The isatin group is widespread in nature and considered to be a privileged building block for drug discovery. In order develop novel SHP1 inhibitors with fluorescent properties as tools biology research, this work designed synthesized series of derivatives. presentive compound

Language: Английский

Citations

3
Comparative study of catalytic performance of TiP and Ti-ATMP towards dihydropyrimidinones synthesis DOI

Mithil Kevadiya,

Kalpana C. Maheria

Research on Chemical Intermediates, Journal Year: 2025, Volume and Issue: unknown

Published: May 11, 2025

Language: Английский

Citations

0
A Brief Review Depending on the Chemistry of Isatin in Single Pot Technique Towards the Construction of Significant and Valuable Heterocyclic Scaffolds DOI
Animesh Mondal

Letters in Organic Chemistry, Journal Year: 2024, Volume and Issue: 21(11), P. 929 - 957

Published: March 28, 2024

Abstract: The term isatin and its derivative-based MCRs have emerged over the years as a versatile, environment-friendly, very promising platform for construction of highly enabling bioactive organic scaffolds such drugs, natural products, pharmaceuticals etc. In world recent advancements, one-pot strategy based on has come to forefront synthetic chemistry activation small molecules. This present survey touched employed past decade sketch creation various types molecules consisting heterocyclic or spiro-heterocyclic skeletons via methodology.

Language: Английский

Citations

1
Incredible Indolinedione Derivatives Nucleus in the Development of Anti‐Diabetic Drugs: Exploring the Mechanistic Studies, Design, and Structure‐Activity Relationship DOI

Aanchal Khanna,

Jyoti Jyoti, Nitish Kumar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract Diabetes mellitus, a prevalent metabolic disorder, necessitates continuous exploration for innovative therapeutic agents. Indolinedione has garnered attention its potential as an antidiabetic scaffold structurally diverse nucleus. The search novel and effective agents led to the of natural compounds synthetic derivatives. review commences with in‐depth biochemical underpinnings diabetes emphasizing rational design strategies employed modifying indolinedione nucleus, encompassing various methodologies aimed at enhancing pharmacological properties docking studies. multifaceted derivatives offer fertile ground further in preclinical clinical As research this field progresses, may emerge valuable addition arsenal therapeutics, providing new avenues management mellitus.

Language: Английский

Citations

0