Photoredox-Enabled Direct and Three-Component Difluoroalkylative Modification of N-Aryl Glycinates DOI
Fangyuan Yu,

Daoyi Yang,

Yuanlin Yang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(4), P. 1072 - 1077

Published: Jan. 18, 2025

A Cu(I) photoredox-enabled reaction that selectively incorporates a difluoroalkyl group into N-aryl glycine derivatives has been established. Using bench-stable [Ph3PCF2H]+Br- salt, the -CF2H could be installed either directly on α-carbon of backbone or in three-component fashion using an alkene as bridge. series have evaluated, providing access to diverse unnatural amino esters and dipeptides with -CHF2 unit. The studies compatibility other perfluorinated alkyl radical precursors showed selectivity direct α-coupling is closely associated electronic property radical, while works well most cases.

Language: Английский

Photoredox-Enabled Direct and Three-Component Difluoroalkylative Modification of N-Aryl Glycinates DOI
Fangyuan Yu,

Daoyi Yang,

Yuanlin Yang

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(4), P. 1072 - 1077

Published: Jan. 18, 2025

A Cu(I) photoredox-enabled reaction that selectively incorporates a difluoroalkyl group into N-aryl glycine derivatives has been established. Using bench-stable [Ph3PCF2H]+Br- salt, the -CF2H could be installed either directly on α-carbon of backbone or in three-component fashion using an alkene as bridge. series have evaluated, providing access to diverse unnatural amino esters and dipeptides with -CHF2 unit. The studies compatibility other perfluorinated alkyl radical precursors showed selectivity direct α-coupling is closely associated electronic property radical, while works well most cases.

Language: Английский

Citations

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