One-Pot Synthesis of 3,4-Dihydroisoquinolin-1(2h)-Ones Via a Sequential Ugi-4cr and Nucleophilic Substitution Reaction DOI

Hong‐Ling Pan,

Han‐Han Kong,

Ding Ming‐Wu

et al.

Published: Jan. 1, 2024

Language: Английский

One-pot Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones via a Sequential Ugi-4CR and Nucleophilic Substitution Reaction DOI

Hong‐Ling Pan,

Han‐Han Kong, Ming‐Wu Ding

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134609 - 134609

Published: March 1, 2025

Language: Английский

Citations

0
One-Pot Regioselective Synthesis of Spiroimidazolidinones via a Sequential Ugi 4CR/Azide-Isocyanide Coupling/Cyclization/Rearrangement/Hydroxylation Reaction DOI

Yan‐Mei Yan,

Hongbo Tong, Zhenxing Ren

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Herein a novel and robust methodology to spiroimidazolidinones has been developed under mild reaction. The reaction of (Z)-2-azido-3-phenylacrylic acids 1, aldehydes 2, amines 3, isocyanides 4, 6 produced regioselectively in 71–88% yields via sequential Ugi 4CR/Pd(0) catalyzed azide-isocyanide coupling/cyclization/rearrangement/hydroxylation Furthermore, the easily accessible starting materials, high bond-forming efficiency, broad substituent tolerance make this strategy useful synthetic medicinal chemistry.

Language: Английский

Citations

0
De novo Synthesis of Chiral 3,4‐DihydroquinazolinesviaOne‐Pot Enantioselective Ugi‐Azide/Cyclization Sequences† DOI

Zu‐Kui Xie,

Jun‐Jun Ding,

Yi‐Ming Ou

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(18), P. 2140 - 2146

Published: May 7, 2024

Comprehensive Summary Herein, we reported a precise de novo synthesis of chiral 3,4‐dihydroquinazoline frameworks via one‐pot anionic stereogenic‐at‐cobalt(III) complex‐catalyzed enantioselective Ugi‐azide/Pd‐catalyzed cyclization sequence. This powerful protocol involves 5 components and 2 catalytic systems, delivering 3,4‐dihydroquinazolines with excellent enantioselectivities (up to 94% ee). The preliminary antifungal experiments suggest that both Ugi‐adducts have great potential in inhibiting plant pathogens such as Trichoderma viride Fusarium graminearum .

Language: Английский

Citations

2
One-Pot Synthesis of 3,4-Dihydroisoquinolin-1(2h)-Ones Via a Sequential Ugi-4cr and Nucleophilic Substitution Reaction DOI

Hong‐Ling Pan,

Han‐Han Kong,

Ding Ming‐Wu

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0