Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
19(20)
Published: July 31, 2024
Synthesis
of
functionalized
1,3-indandiones
containing-cyclopentenones
and
-benzotropones
has
been
achieved
by
the
reaction
1,5-diphenylpenta-1,4-diyn-3-ones
with
1,3-indandiones,
bindone
respectively.
The
developed
method
involves
Michael-anti-Michael
addition
cascade
reactions
under
transition-metal-free
conditions.
This
is
first
report
to
synthesise
diverse
benzotropone
fused
transition
metal-free
conditions
from
bindone.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(19), P. 4117 - 4121
Published: May 9, 2024
We
have
developed
an
efficient
protocol
for
the
synthesis
of
spiro[indoline-pyridine]dicarboxylates
and
substituted
alkylidene
oxindoles
through
[3
+
3]
cycloaddition
Michael
addition
individually
by
azomethine
ylides
various
MBH
carbonates
isatins.
The
selective
generation
cyclic
products
chain
was
achieved
changing
substituents
at
3-position
oxindoles.
features
this
method
include
convenient
catalysts,
mild
reaction
conditions,
broad
substrate
scopes.
Beilstein Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
20, P. 1436 - 1443
Published: June 28, 2024
An
efficient
protocol
for
the
synthesis
of
polyfunctionalized
tetrahydrocyclopenta[4,5]pyrrolo[2,3-
b
]pyridine-3,4b,5,6,7(1
H
)-pentacarboxylates
was
developed
by
a
three-component
reaction.
In
absence
any
catalyst,
reaction
alkyl
isocyanides,
dialkyl
but-2-ynedioates
and
5,6-unsubstituted
1,4-dihydropyridines
in
refluxing
acetonitrile
afforded
high
yields
with
diastereoselectivity.
The
finished
situ
generation
activated
5-(alkylimino)cyclopenta-1,3-dienes
from
addition
isocyanide
to
two
molecules
sequential
formal
[3
+
2]
cycloaddition
1,4-dihydropyridine.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(15), P. 10854 - 10866
Published: July 12, 2024
A
convenient
synthetic
protocol
for
diverse
fused
chromenes
was
successfully
developed
by
a
three-component
reaction
of
alkyl
isocyanides,
dialkyl
but-2-ynedioates,
and
various
cyclic
1,3-dipolarophiles
containing
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(21), P. 15472 - 15489
Published: Oct. 15, 2024
We
have
developed
a
convenient
synthetic
protocol
for
efficient
construction
of
significant
dihydrobenzofuran
and
benzofuran
scaffolds
by
Lewis
base-mediated
annulation
reaction
ortho-iminophenols
ortho-vinylphenols
with
MBH
carbonates
isatins
under
mild
metal-free
conditions.
The
selective
generation
different
kinds
derivatives
was
successfully
achieved
employing
substituted
isatin-derived
ortho-N-tosyliminophenols
ortho-vinylphenols.
features
included
broad
substrate
scopes,
excellent
functional
group
compatibility,
high
molecular
diversity,
atomic
economy.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(4)
Published: Jan. 1, 2025
Abstract
A
convenient
synthetic
protocol
for
novel
spiro[indoline‐3,2′‐pyrrolo[2,1‐
a
]isoquinoline]
and
spiro[indoline‐3,2′‐pyrrolo[1,2‐
]quinoline]
motifs
was
successfully
developed
by
three‐component
reaction
of
isoquinoline
(quinoline),
cyclohexyl
isocyanide,
isatylidene
malononitriles.
In
the
absence
any
catalyst,
isoquinoline,
malononitriles
in
refluxing
dichloromethane
gave
functionalized
]isoquinolines]
good
yields
with
high
diastereoselectivity.
However,
similar
quinoline
afforded
]quinolines]
about
2:1
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 286 - 295
Published: Feb. 6, 2025
In
this
paper,
the
nucleophilic
substitution
reactions
of
various
N-
and
P-containing
nucleophiles
to
MBH
carbonates
isatins
were
investigated.
Diverse
functionalized
3-substituted
oxindole
derivatives
successfully
prepared
in
satisfactory
yields
with
high
diastereoselectivity.
addition,
base-promoted
dimerization
isatin
afforded
ethylene-bridged
bis(3-methylene)oxindole
nearly
4:1
diastereomeric
ratios.
The
relative
configurations
polycyclic
compounds
clearly
elucidated
by
determination
several
single
crystal
structures.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Here,
we
revealed
a
convenient
synthetic
protocol
for
unique
pyrido[2,3-c]pyridazine
and
pyrido[3,2-e][1,2]oxazine
scaffolds
with
excellent
regioselectvity
diastereoselectivity.
The
functionalized
pyrido[2,3-c]
pyridazines
were
successfully
synthesized
via
Cs2CO3-promoted
[4
+
2]
cycloaddition
reaction
of
α-halogenated
N-tosylhydrazones
or
N-acylhydrazones
5,6-unsubstituted
1,4-dihydropyridines
under
mild
conditions.
Additionally,
the
similar
base-promoted
α-chlorogenated
oximes
afforded
pyrido[3,2-e][1,2]oxazines
in
satisfactory
yields.
features
this
included
conditions,
broad
substrate
scopes,
high
functional
group
tolerance,
significant
atomic
economy.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 17, 2024
Abstract
The
diverse
functionalized
dihydrobenzofuran‐fused
spirocyclopentane‐1,2‐diindolin‐one
scaffolds
were
conveniently
synthesized
by
base
promoted
domino
cyclization
reaction
of
MBH
(Morita‐Baylis‐Hillmann)
carbonates
isatins
and
3‐(
o
‐hydroxybenzylidene)indolin‐2‐ones.
reactions
maleimides
formates
with
‐hydroxybenzylidene)indolin‐2‐ones
afforded
polycyclic
dispiro[indoline‐3,4′‐benzofuro[2′,3′:1,5]cyclopenta[1,2‐
c
]pyrrole‐5′,3′′‐indolines]
dispiro[indoline‐3,1′‐cyclopenta[
b
]benzofuran‐2′,3′′‐indolines]
in
good
yields
high
diastereoselectivity.
More
importantly,
DMAP
facilitated
annulation
nitriles
selectively
resulted
dispiro[indoline‐3,1′‐cyclopentane‐2′,3′′‐indolines],
while
Cs
2
CO
3
gave
relative
configurations
the
various
compounds
clearly
elucidated
determination
several
single
crystal
structures.
