Cited by Synthesis of nicotinimidamides <i>via</i> a tandem CuAAC/ring-cleavage /cyclization/oxidation four-component reaction and their cytotoxicity

Highly Stereoselective Synthesis of 2-Acyl-3-sulfonamidobut-2-enoates Using Solid Calcium Carbide as a Substitute for Gaseous Acetylene DOI

Wang Botao,

Xinjie You,

Jiao Wang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(29), P. 6269 - 6273

Published: July 17, 2024

Multifunctional group compounds, 2-acyl-3-sulfonamidobut-2-enoates, are efficiently constructed using solid calcium carbide as an alkyne source through the simultaneous formation of two bonds in one step. The salient features this protocol use inexpensive, abundant, and easy-to-use a substitute for flammable explosive gaseous acetylene, low-cost catalyst, mild conditions, wide substrate scope, high stereoselectivity, satisfactory yield, simple manipulation. This method can also be extended to gram scale.

Language: Английский

Citations

Divergent Synthesis of Enynals and Dihydrobenzo[f]isoquinolines via Deoxyalkynylation of Enaminones Enabled by the Cooperative Action of Tf₂O/Pd/Cu DOI

Jianping Lin,

Jiakai Tian,

Lu Yu

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16419 - 16425

Published: Oct. 28, 2024

A variety of enynals and dihydrobenzo[

Language: Английский

Citations

Synthesis of 2‐Aminopyridine Derivatives via a Tandem CuAAC/Ring‐Cleavage/[4+2]‐Cycloaddition/Rearrangement Reaction Sequence DOI

Weiguang Yang,

Guanrong Li,

Danyang Luo

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(17), P. 3689 - 3694

Published: June 22, 2024

Abstract 2 H ‐Azirines are an important class of small‐ring heterocycle that have been employed as versatile synthetic building blocks. Herein, a one‐pot CuAAC/ring‐cleavage/[4+2]‐cycloaddition/rearrangement reaction sequence involving terminal ynones, sulfonyl azides and ‐azirines is reported leads to 2‐aminopyridine derivatives. In the first step, highly reactive N ‐sulfonyl α ‐acylketenimines generated, via CuAAC/ring‐cleavage process, from ynones these undergo inverse electron‐demand Diels–Alder cycloaddition reactions with form (isolable) 1,3‐oxazines themselves base‐promoted ring‐cleavage rearrangement afford title compounds.

Language: Английский

Citations

One-Step Construction of 2-Methylquinazolin-4(3H)-ones Using Solid Calcium Carbide as an Alternative to Gaseous Acetylene DOI

Botao Wang,

Zhiqiang Wang,

Xinjie You

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

2-Methylquinazolin-4(3H)-ones were efficiently constructed using solid calcium carbide as an alkyne source, 2-aminobenzamides or 2-aminobenzohydrazides substrates, and p-tolylsulfonyl azide a mediator through simultaneous formation of two C–N bonds in one step. The salient features this protocol are the use inexpensive, abundant easy-to-use source substitute for flammable explosive gaseous acetylene, low-cost catalyst, wide substrate scope, satisfactory yield, simple manipulation. This method can also be extended to gram scale.

Language: Английский

Citations

Synthesis of nicotinimidamides via a tandem CuAAC/ring-cleavage /cyclization/oxidation four-component reaction and their cytotoxicity DOI

Xi Chen,

Guanrong Li,

Zixin Huang

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(35), P. 25844 - 25851

Published: Jan. 1, 2024

Nicotinamide and its derivatives, recognized as crucial drug intermediates, have been a focal point of extensive chemical modifications rigorous pharmacological studies. Herein, series novel nicotinamide nicotinimidamides, were synthesized

Language: Английский

Citations