Visible-light-catalyzed Synthesis of Amino Alcohols from N,N-dimethylaniline and Aryl Aldehyde DOI
Jiahui Jin, Yi-Jian Ma,

Yu-Yun Yin

et al.

Chemistry Letters, Journal Year: 2024, Volume and Issue: 53(6)

Published: June 1, 2024

Abstract Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalyst to form amino alcohols under mild conditions, offering convenient sustainable methodology. The could be easily scaled up through continuous flow with high yield. A series alcohol compounds were synthesized photocatalyst. reaction. mechanism has been investigated the aid density functional theory (DFT) calculations.

Language: Английский

Copper-Catalyzed Successive Radical Reactions of Glycine Derivatives DOI

Youwan Ye,

Dong-Sheng Ji,

Chenxing Zhou

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(4), P. 1054 - 1059

Published: Jan. 16, 2025

Here, we present a three-component successive radical addition strategy for the preparation of complex noncanonical α-amino acids from easily available glycine derivatives, alkenes, and aryl sulfonium salts via copper-catalyzed photoredox-neutral catalytic cycle. The utility this method is further demonstrated by its application in late-stage site-selective modifications residues short peptides. It worth noting that only 1 mol % copper catalyst required reaction, demonstrating high efficiency.

Language: Английский

Citations

1
Recent Advances in Covalent Organic Frameworks as Photocatalysts for Organic Transformations DOI

Yongjian Du,

Jinwen Jiao, Ziyi Zhang

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116253 - 116253

Published: March 1, 2025

Language: Английский

Citations

0
Blue‐Light‐Induced Stereoselective Synthesis of α‐Alkylated Amino Acid Derivatives DOI Open Access

Hongying Fan,

Meiling Ye,

Xue Zhang

et al.

European Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract A photoredox‐catalyzed decarboxylative C( sp 3 )−H alkylation of glycine derivatives, utilizing (+)/(−)‐camphorsultam as a chiral auxiliary and alkyl N ‐hydroxyphthalimide (NHP) ester radical precursor, has been developed, providing an efficient approach for the stereoselective synthesis valuable enantioenriched unnatural α ‐alkylated amino acid derivatives. The methodology operates under mild conditions, demonstrates broad substrate tolerance, exhibits excellent stereoselectivity. Preliminary mechanistic investigations indicate that reaction proceeds via pathway.

Language: Английский

Citations

0
Visible-light-catalyzed Synthesis of Amino Alcohols from N,N-dimethylaniline and Aryl Aldehyde DOI
Jiahui Jin, Yi-Jian Ma,

Yu-Yun Yin

et al.

Chemistry Letters, Journal Year: 2024, Volume and Issue: 53(6)

Published: June 1, 2024

Abstract Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalyst to form amino alcohols under mild conditions, offering convenient sustainable methodology. The could be easily scaled up through continuous flow with high yield. A series alcohol compounds were synthesized photocatalyst. reaction. mechanism has been investigated the aid density functional theory (DFT) calculations.

Language: Английский

Citations

1