Structural, Solvatochromic, NLO, and Molecular Docking Studies of Positional Isomers of Chlorobenzaldehyde Phenylhydrazone: An Experimental and Computational Investigation

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1329, P. 141425 - 141425

Published: Jan. 12, 2025

Language: Английский

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Isothiocyanates: happy-go-lucky reagents in organic synthesis

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(19), P. 3772 - 3798

Published: Jan. 1, 2024

This review summarises the reactivity and synthetic procedures of aryl acyl isothiocyanates, a versatile reagent with multiple reactive centres.

Language: Английский

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Mechanoredox-Enabled Isothiocyanation of Primary Amines Using Piezoelectric Material as the Redox Catalyst

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

A novel mechanoredox-enabled synthesis of aromatic and aliphatic isothiocyanates from primary amines carbon disulfide under ball milling conditions using a piezoelectric material (BaTiO3) as the redox catalyst has been developed. This method displays several features, such short reaction time, operational simplicity, room temperature air conditions, minimal solvent, broad substrate scope, recyclable cheap catalyst. Preliminary mechanistic studies revealed that highly polarized acted single-electron transfer (SET) oxidation reagent for key desulfurization process.

Language: Английский

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Antifungal and anti-biofilm effects of hydrazone derivatives on Candida spp

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Nov. 26, 2024

Worldwide, invasive candidiasis are a burden for the health system due to difficulties manage patients, increasing of resistance current therapeutics and emergence naturally resistant species Candida. In this context, development innovative antifungal drugs is urgently needed. During candidiasis, yeast submitted many stresses (oxidative, thermic, osmotic) in human host. order resist develops different strategy, especially biosynthesis trehalose. Starting from 3D structural data TPS2, an enzyme implicated trehalose biosynthesis, we identified hydrazone as interesting scaffold design new drugs. Interestingly, our derivatives which demonstrate anti-biofilm effects on Candida spp., non-toxic vitro vivo models (Galleria mellonella).

Language: Английский

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Elemental Sulfur Promoted Cyclization of o‐Chloronitrobenzenes and Aryl Isothiocyanates to Furnish 2‐Aminobenzothiazoles

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Abstract Methods to afford 2‐aminobenzothiazoles often involve the use of o ‐aminothiophenols or aniline‐typed precursors. Herein we describe a method furnish through cyclization ‐chloronitrobenzenes and aryl isothiocyanates with assistance elemental sulfur. From perspective step economy, our strategy allows for direct nitroarene precursors without further reduction anilines. The scope reaction respect both substrates was investigated, it found that electronic properties isothiocyanate important obtaining acceptable yields.

Language: Английский

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C–H Trifluoromethylthiolation of aldehyde hydrazones

Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 2883 - 2890

Published: Nov. 12, 2024

The selective C–H trifluoromethylthiolation of aldehyde hydrazones afforded interesting fluorinated building blocks, which could be used as a synthetic platform. Starting from readily available (hetero)aromatic and aliphatic hydrazones, the formation C–SCF 3 bond was achieved under oxidative mild reaction conditions in presence AgSCF salt via one-pot sequential process (28 examples, up to 91% yield). Mechanistic investigations revealed that active species transformation.

Language: Английский

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