The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16351 - 16362
Published: Nov. 4, 2024
Chemoselective insertion of in situ generated α-imino rhodium carbene onto the O–H bond 2-aminobenzyl alcohols over N–H followed by [1,3]-alky shift has been successfully accomplished for synthesis amine tethered ketone derivatives. The resultant product was further cyclized under acidic conditions to afford biologically important 3-aminoquinolines. Successful integration chemoselective insertion-cum-rearrangement and cyclization one pot offered access various 3-aminoquinolines a good yield. Conversion into biological motifs also demonstrated.
Language: Английский