Abstract
The
iron
(ІІІ)‐promoted
tandem
cyclization
of
1‐(2‐(allyloxy)aryl)‐1
H
‐indoles
with
diselenides
has
been
developed
for
the
preparation
seleno‐benzo[2,3][1,4]oxazepino[4,5‐a]indole
derivatives.
investigation
to
determine
best
reaction
conditions
indicated
use
(0.2
mmol)
(1.5
equiv.)
and
iron(III)
chloride
in
acetonitrile
at
room
temperature
under
air,
more
than
48
examples
were
obtained.
features
access
selenized
7‐membered
containing
nitrogen‐oxygen
heterocyclic
skeleton,
which
also
represents
a
7‐exo‐trig
process
1‐(2‐((2‐methylallyl)oxy)aryl)‐1
diselenides.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(9), P. 6117 - 6125
Published: April 24, 2024
The
first
paired
electrolysis-enabled
arylation
of
quinoxalin-2(1H)-ones
was
achieved
using
cyanoarenes
as
the
reagents.
A
variety
3-arylquinoxalin-2(1H)-ones
with
various
important
functional
groups
were
obtained
in
moderate
to
good
yields
under
metal-
and
chemical
oxidant-free
conditions.
With
a
pair
reductive
oxidative
processes
occurring
among
substrates
reaction
intermediates,
power
consumption
can
be
dramatically
reduced.
This
review
highlights
the
recent
advances
in
multi-component
reactions
for
synthesizing
heterocyclic
compounds
via
green
approaches
including
photoredox
catalysis,
electrochemical
activation,
catalyst-free
methods
and
use
of
water
as
sole
solvent.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8632 - 8640
Published: June 6, 2024
Herein,
we
disclosed
a
highly
efficient
pathway
toward
3-selenylated
chromone
derivatives
via
electrocatalytic
cascade
selenylation/cyclization/deamination
of
2-hydroxyaryl
enaminones
with
diselenides.
This
method
showed
mild
conditions,
easy
operation,
wide
substrate
scope,
and
good
functional
group
tolerance.
Furthermore,
this
electrosynthesis
strategy
was
amendable
to
scale-up
the
reaction.
Additionally,
preliminary
experiments
revealed
that
reaction
probably
proceeded
cation
instead
radical
pathway.
A
mild
and
efficient
FeCl
3
-catalyzed
oxidative
diselenylation
of
pyrrole-tethered
indoles
has
been
achieved
by
using
RSeSeR
as
the
source
selenium
m
-chloroperoxybenzoic
acid
(
CPBA)
oxidant
(yields
17–70%).
ChemCatChem,
Journal Year:
2024,
Volume and Issue:
16(20)
Published: June 27, 2024
Abstract
Herein,
a
method
for
the
assembly
of
biologically
valuable
3‐selenospiro[4,5]decatrienones
through
CuBr
2
‐catalyzed
ispo
‐cyclization
Se
powder,
boronic
acids,
and
N
‐(
p
‐methoxyaryl)propiolamides
has
been
established.
In
this
protocol,
noble
transition
metal,
prefunctionalized
selenylation
reagent,
strong
chemical
oxidant
are
not
employed.
This
feature
wide
substrate
scope,
good
functional
group
tolerance,
easy
operation,
employing
earth‐abundant
metal
as
catalyst
green
air
oxidant.
Furthermore,
several
derivatizations
performed
to
showcase
practicability
our
strategy.
Abstract
Electrosynthesis
of
selenylated‐oxazolone
derivatives
via
cascade
selenylation/cyclization
ynamides
was
disclosed.
A
series
diaryl
diselenides,
dialkyl
and
heteroaryl‐substituted
tolerated
in
this
protocol
delivered
4‐selenyloxazolones
28–83%
yields.
The
scale‐up
reaction
the
oxidation
performed
to
showcase
practicability
method.
Furthermore,
mechanistic
experiments
indicated
that
a
cationic
pathway
instead
radical
probably
involved.
