Fe‐Catalyzed C‐N/C‐S Bonds Formation via Activation of Csp³‐H Bond of Methylarenes: A Straightforward Tandem Oxidative Process to Access Benzazoles

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 25, 2025

ABSTRACT Fe‐catalyzed tandem cross‐dehydrogenative coupling of the methylarenes with o ‐phenylenediamine/2‐aminothiophenol as partners has been developed for synthesis benzimidazoles and benzothiazoles. Various 2‐aryl benzimidazoles/thiazoles were synthesized high efficiency from cost‐effective raw materials using tert ‐butyl hydroperoxide (TBHP) an environmentally benign oxidant without any co‐promoter additional oxidizing reagent.

Language: Английский

Synthesis of Functionalized Indoles by an Iridium-Catalyzed N–H Insertion Cascade: Nucleophilic Cyclization of Naphthylamines with α-Diazocarbonyl Compounds

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

A novel iridium-catalyzed [3 + 2] annulation of naphthylamines and α-diazocarbonyl compounds was developed for the rapid assembly densely functionalized indoles. This new catalytic process represents first example a cascade intramolecular nucleophilic cyclization by N-H insertion amines. Various could be obtained in high yields with excellent functional group tolerance. The reaction affords valuable indole derivatives, enabling expedient access to heterocyclic analogues not easily accessible other methods.

Language: Английский

Rhodium-catalyzed transformations of diazo compounds via a carbene-based strategy: recent advances

RSC Advances, Journal Year: 2024, Volume and Issue: 14(53), P. 39337 - 39352

Published: Jan. 1, 2024

As a carbene precursor, diazo compounds incorporate in Rh-catalyzed synthesis of heterocycles, carbocycles and functionalized compounds. The reaction involves C–H activation, insertion an annulation/functionalization sequence.

Language: Английский