Synthesis of 3-Benzazepines via Cobalt-Catalyzed C–H Bond Functionalization with CaC2 as the Acetylene Source DOI
Aleksandrs Cizikovs,

Paula A. Zagorska,

Liene Grigorjeva

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(44), P. 9536 - 9540

Published: Oct. 25, 2024

Herein, we report a simple method for the synthesis of 3-benzazepine derivatives via cobalt-catalyzed, picolinamide-directed α-amidoacrylate C(sp2)–H bond functionalization approach. The reactions utilize calcium carbide as an inexpensive, easy-to-handle, and solid acetylene source, CoCl2 reaction catalyst. Excellent functional group tolerance is observed, yielding diverse substituted in good to excellent yields.

Language: Английский

Synthesis of 3-Benzazepines via Cobalt-Catalyzed C–H Bond Functionalization with CaC2 as the Acetylene Source DOI
Aleksandrs Cizikovs,

Paula A. Zagorska,

Liene Grigorjeva

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(44), P. 9536 - 9540

Published: Oct. 25, 2024

Herein, we report a simple method for the synthesis of 3-benzazepine derivatives via cobalt-catalyzed, picolinamide-directed α-amidoacrylate C(sp2)–H bond functionalization approach. The reactions utilize calcium carbide as an inexpensive, easy-to-handle, and solid acetylene source, CoCl2 reaction catalyst. Excellent functional group tolerance is observed, yielding diverse substituted in good to excellent yields.

Language: Английский

Citations

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