Concerted or Stepwise? An Experimental and Computational Study to Reveal the Mechanistic Change as a Result of the Substituent Effects

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

This study investigates the Cope elimination reaction, focusing on mechanistic shift between concerted and stepwise pathways influenced by substituent effects. Experimental approaches, including kinetic isotope effects (KIEs) linear free energy relationships (LFERs), alongside density functional theory (DFT) computations, were employed to explore influence of substituents reaction kinetics pathways. Our findings reveal temperature- substituent-dependent partitioning syn-β E1cB mechanism, providing deeper insights into diversity reactions.

Language: Английский

Construction of central and axial chirality via Pd(II)/Bim-catalyzed asymmetric dearomative Michael reaction of polycyclic tropones

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(67), P. 8908 - 8911

Published: Jan. 1, 2024

A highly enantioselective Pd/Bim-catalyzed dearomative Michael reaction applying polycyclic tropones as non-benzenoid aromatic acceptors and arylboronic acids aryl pronucleophiles has been developed. The bridged biaryls bearing central axial chirality, including pentacyclic cyclohepta[

Language: Английский