The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Herein, we report an efficient, organophotocatalyzed decarboxylative (amino)alkylation of azomethine imines using readily available carboxylic acids as alkylating agents. This transformation exhibits wide scope, and a variety acids, including glycine derivatives, were employed radical precursors. The use 4CzIPN the photocatalyst allowed application nonbenzylic secondary tertiary also, overcoming previous limitations. applicability nonprefunctionalized precursors, mild conditions are highlights this method. intermediacy key intermediates was established by trapping experiments.

Language: Английский