Recent Advances in Fluorination Reactions via De‐Carboxylative and De‐Oxygenative Strategies: A Perspective DOI
Nikita Goel,

Poonam Kumari,

Gunjan Gunjan

et al.

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Organic fluorine compounds encompass a vast and diverse variety of species that possess unique biological activity due to the presence atoms. Fluorine is highly electronegative, increases lipophilicity (fat‐solubility) hydrophobicity (water‐repellent nature) molecules, often exhibit remarkable chemical thermal stability. This especially useful in drug design, as it can improve bioavailability pharmaceutical help them interact more effectively with membranes. The growing demand for fluorinated materials science, agrochemicals, medicine has made selective incorporation into organic molecules challenging but necessary component modern synthesis. Development C−F building blocks are invaluable synthesis their ability impart stability, selectivity, reactivity molecules. article provides detailed analysis two popular fluorination processes: deoxyfluorination decarboxyfluorination. Deoxyfluorination process enhancing physicochemical properties by replacing hydroxyl groups Decarboxyfluorination type reaction where transformation carboxylic acid derivatives compounds. various fluorinating reagents, mechanistic processes, synthetic uses substrate scope covered this section. When combined, these novel strategies provide effective focused approaches production bonds, offering resources obtaining review mainly focuses on construction via deoxygenative decarboxylative since 2011. We hope offers conceptual overview inspires further advancements efficient bond.

Language: Английский

Recent Advances in Fluorination Reactions via De‐Carboxylative and De‐Oxygenative Strategies: A Perspective DOI
Nikita Goel,

Poonam Kumari,

Gunjan Gunjan

et al.

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Organic fluorine compounds encompass a vast and diverse variety of species that possess unique biological activity due to the presence atoms. Fluorine is highly electronegative, increases lipophilicity (fat‐solubility) hydrophobicity (water‐repellent nature) molecules, often exhibit remarkable chemical thermal stability. This especially useful in drug design, as it can improve bioavailability pharmaceutical help them interact more effectively with membranes. The growing demand for fluorinated materials science, agrochemicals, medicine has made selective incorporation into organic molecules challenging but necessary component modern synthesis. Development C−F building blocks are invaluable synthesis their ability impart stability, selectivity, reactivity molecules. article provides detailed analysis two popular fluorination processes: deoxyfluorination decarboxyfluorination. Deoxyfluorination process enhancing physicochemical properties by replacing hydroxyl groups Decarboxyfluorination type reaction where transformation carboxylic acid derivatives compounds. various fluorinating reagents, mechanistic processes, synthetic uses substrate scope covered this section. When combined, these novel strategies provide effective focused approaches production bonds, offering resources obtaining review mainly focuses on construction via deoxygenative decarboxylative since 2011. We hope offers conceptual overview inspires further advancements efficient bond.

Language: Английский

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