Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

A Rh(III)-catalyzed dearomative C3 alkoxylation of indoles via cascade C(sp2)-H activation and 1,2-alkoxyl shift rearrangement has been developed. This method provides an efficient strategy to rapidly assemble 3-alkoxyindolin-2-one scaffolds using alcohols as alkoxyl sources. Mechanistic studies indicate that indolyl C2 followed by Ag(I)/Cu(II)-mediated migration is involved in this transformation.

Language: Английский