Palladium-Catalysed Spiro-Cyclisation of Substituted Amino Acids with Maleimides via γ-C(sp³)–H Bond Activation

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Achieving the site-selective functionalization of unactivated C(sp3)-H bonds remains a major challenge in organic synthesis. Herein, we report an efficient method for synthesis spiro pyrrolidine molecules via γ-C(sp3)-H bond activation substituted amino acids. A variety acid and alcohol derivatives, as well dipeptides, were functionalized using this method. Also, spirocyclization optically active substrates provided potential route preparing separable diastereomers pure enantiomeric form. Moreover, some mechanistic insights have been conducted to propose feasible reaction mechanism present reaction.

Language: Английский

Late-Stage Modification of Peptides with Maleimides through Palladium-Catalyzed β-C(sp³)–H Alkylation

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Transition-metal-catalyzed C-H activation has proven to be a powerful tool for the late-stage modification of peptides. We herein report method site-selective alkylation peptides with maleimides through Pd-catalyzed β-C(sp

Language: Английский

Synthetic approach of hydroxy-acetophenone-directed Rh(III) catalyzed C-H o-alkylation via 1,4 addition: Insights from DFT and docking methodology

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1327, P. 141248 - 141248

Published: Dec. 27, 2024

Language: Английский