A Novel Strategy for the Synthesis of N-Alkylated Oxindoles DOI
Duong Tien Anh,

Daniel Baecker,

Nguyen Duc Thien

et al.

Synlett, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract The synthesis of N-alkylated oxindoles remains an important focus in organic chemistry, due to their common occurrence bioactive compounds and pharmaceutical agents. An efficient novel strategy for alkylating the oxindole scaffold at N-1 position is described. By using (N-methylpyrrol-2-yl)methylidene as a protecting group competing C-3 position, this methodology provides simple mild procedure convert various into corresponding N-benzylated derivatives moderate good overall yields (up 67%).

Language: Английский

A Novel Strategy for the Synthesis of N-Alkylated Oxindoles DOI
Duong Tien Anh,

Daniel Baecker,

Nguyen Duc Thien

et al.

Synlett, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract The synthesis of N-alkylated oxindoles remains an important focus in organic chemistry, due to their common occurrence bioactive compounds and pharmaceutical agents. An efficient novel strategy for alkylating the oxindole scaffold at N-1 position is described. By using (N-methylpyrrol-2-yl)methylidene as a protecting group competing C-3 position, this methodology provides simple mild procedure convert various into corresponding N-benzylated derivatives moderate good overall yields (up 67%).

Language: Английский

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