Recent Advances in Visible Light-Induced C-H Functionalization of Imidazo[1,2-a]pyridines

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 607 - 607

Published: Jan. 30, 2025

The imidazo[1,2-a]pyridine skeleton is widely present in many natural products and pharmaceutical agents. Due to its impressive significant biological activities, such as analgesic, anti-tumor, antiosteoporosis, anxiolytic properties, the derivatization of has attracted widespread attention from chemists. In recent years, progress been made imidazo[1,2-a]pyridines through direct C-H functionalization, especially visible light induction. This review highlights advances light-induced functionalization during past ten some reaction mechanisms are also discussed.

Language: Английский

Identification of Imidazo[1,2-a]pyridine-3-amine as a Novel Drug-like Scaffold for Efficious Ferroptosis Inhibition in vivo

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117516 - 117516

Published: March 1, 2025

Language: Английский

Rongalite as a Methylene Surrogate: Synthesis of Heterodiarylmethanes via C(sp²)-H Functionalization

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

An efficient method for the synthesis of heterodiarylmethanes through coupling imidazo[1,2-a]pyridines and heteroarenes using indoles employing rongalite as a methylenating reagent has been developed. This regioselective C–H functionalization provides wide range imidazo[2,1-b]thiazole. Here, plays crucial role in generating C1 unit situ, which triggers heterodiarylmethylation process. The use inexpensive (ca. $0.03/1 g), mild reaction conditions, gram-scale are some key features this methodology.

Language: Английский